Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 13/20 | 0.45 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.43 |
| ▸ | MERTK | Q12866 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.41 |
| ▸ | MKNK1 | Q9BUB5 | 4/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 4/20 | 0.40 |
| ▸ | TTK | P33981 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2321921 | 0.92 | PLK1 (0.45) | PLK1TYRO3BRD4BRDTTTK | |
| SCHEMBL2325615 | 0.91 | PLK1 (0.45) | PLK1BRD4BRDTTTK | |
| SCHEMBL2323760 | 0.91 | PLK1 (0.45) | PLK1TYRO3BRD4BRDTMKNK1 | |
| SCHEMBL2325152 | 0.90 | PLK1 (0.44) | PLK1BRD4BRDTTTK | |
| SCHEMBL2325432 | 0.90 | PLK1 (0.44) | PLK1BRD4BRDTTTK | |
| SCHEMBL2325894 | 0.90 | PLK1 (0.46) | PLK1MERTKBRD4BRDTTTK | |
| SCHEMBL2321132 | 0.89 | PLK1 (0.44) | PLK1TYRO3BRD4BRDTTTK | |
| SCHEMBL2326310 | 0.89 | PLK1 (0.43) | PLK1BRD4BRDTTTK | |
| SCHEMBL2329792 | 0.88 | PLK1 (0.42) | PLK1BRD4BRDTMKNK2TTK | |
| SCHEMBL2329486 | 0.88 | PLK1 (0.42) | PLK1BRD4BRDT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2356122-A1 | PROTEIN KINASE INHIBITORS | Vertex Pharmceuticals Incorporated (US) | 2011-08-17 | — | — | EP | claimed |
| WO-2010008454-A1 | PROTEIN KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-01-21 | — | — | WO | claimed |
| EP-2356122-A1 | PROTEIN KINASE INHIBITORS | Vertex Pharmceuticals Incorporated (US) | 2011-08-17 | — | — | EP | disclosed |
| WO-2010008454-A1 | PROTEIN KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-01-21 | — | — | WO | disclosed |