Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 20/20 | 0.68 |
| ▸ | DNER | Q8NFT8 | 2/20 | 0.59 |
| ▸ | BRDT | Q58F21 | 5/20 | 0.56 |
| ▸ | BRD2 | P25440 | 6/20 | 0.56 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.55 |
| ▸ | TSPO | P30536 | 1/20 | 0.55 |
| ▸ | BRD3 | Q15059 | 3/20 | 0.53 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.53 |
| ▸ | JAK2 | O60674 | 1/20 | 0.53 |
| ▸ | BRD1 | O95696 | 1/20 | 0.53 |
| ▸ | CCL2 | P13500 | 1/20 | 0.53 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.53 |
| ▸ | EP300 | Q09472 | 1/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.53 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.53 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3209712 | 0.90 | BRD4 (0.82) | BRD4DNERBRDTBRD2ADORA3 | |
| SCHEMBL23801145 | 0.90 | BRD4 (0.81) | BRD4DNERBRDTBRD2ADORA3 | |
| SCHEMBL18551523 | 0.84 | BRD4 (0.81) | BRD4DNERBRDTBRD2ADORA3 | |
| SCHEMBL12228129 | 0.82 | BRD4 (0.85) | BRD4DNERBRDTBRD2ADORA3 | |
| SCHEMBL31548657 | 0.82 | BRD4 (0.84) | BRD4DNERBRDTBRD2ADORA3 | |
| SCHEMBL25092048 | 0.81 | BRD4 (0.83) | BRD4DNERBRDTBRD2ADORA3 | |
| SCHEMBL18484183 | 0.81 | BRD4 (0.83) | BRD4DNERBRDTBRD2ADORA3 | |
| SCHEMBL3207232 | 0.81 | BRD4 (0.73) | BRD4DNERBRDTBRD2ADORA3 | |
| SCHEMBL23801110 | 0.81 | BRD4 (0.82) | BRD4DNERBRDTBRD2ADORA3 | |
| SCHEMBL18482251 | 0.81 | BRD4 (0.82) | BRD4DNERBRDTBRD2ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1887008-B1 | THIENOTRIAZOLODIAZEPINE COMPOUND AND A MEDICINAL USE THEREOF | MITSUBISHI TANABE PHARMA CORP (JP) | 2021-04-21 | — | — | EP | disclosed |