Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR3 | P22607 | 3/20 | 0.65 |
| ▸ | JAK3 | P52333 | 7/20 | 0.60 |
| ▸ | LCK | P06239 | 4/20 | 0.58 |
| ▸ | JAK2 | O60674 | 2/20 | 0.58 |
| ▸ | JAK1 | P23458 | 4/20 | 0.57 |
| ▸ | TYK2 | P29597 | 1/20 | 0.56 |
| ▸ | EGFR | P00533 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL377810 | 0.91 | FGFR3 (0.70) | FGFR3JAK3LCKJAK2JAK1 | |
| SCHEMBL378153 | 0.88 | FGFR3 (0.72) | FGFR3JAK3LCKJAK2JAK1 | |
| SCHEMBL374009 | 0.87 | FGFR3 (0.75) | FGFR3JAK3LCKJAK2JAK1 | |
| SCHEMBL373491 | 0.87 | FGFR3 (0.58) | FGFR3JAK3LCKJAK2JAK1 | |
| SCHEMBL377530 | 0.87 | FGFR3 (0.73) | FGFR3JAK3LCKJAK2JAK1 | |
| SCHEMBL374002 | 0.85 | FGFR3 (0.80) | FGFR3JAK3LCKJAK2JAK1 | |
| SCHEMBL373147 | 0.85 | FGFR3 (0.73) | FGFR3JAK3LCKJAK2JAK1 | |
| SCHEMBL374218 | 0.85 | FGFR3 (0.70) | FGFR3JAK3LCKJAK2JAK1 | |
| SCHEMBL374716 | 0.84 | FGFR3 (0.75) | FGFR3JAK3LCKJAK2JAK1 | |
| SCHEMBL374567 | 0.84 | LCK (0.74) | FGFR3JAK3LCKJAK2EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761505-B1 | PYRIMIDINE UREA DERIVATIVES AS KINASE INHIBITORS | NOVARTIS AG (CH) | 2011-08-17 | — | — | EP | disclosed |