Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DBH | P09172 | 2/20 | 0.37 |
| ▸ | MAOA | P21397 | 7/20 | 0.34 |
| ▸ | MAOB | P27338 | 5/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | AXL | P30530 | 1/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.31 |
| ▸ | AR | P10275 | 1/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23250742 | 1.00 | DBH (0.37) | DBHMAOAMAOBHDAC4HDAC2 | |
| SCHEMBL23258491 | 1.00 | DBH (0.37) | DBHMAOAMAOBHDAC4HDAC2 | |
| SCHEMBL23250773 | 1.00 | DBH (0.37) | DBHMAOAMAOBHDAC4HDAC2 | |
| SCHEMBL23258702 | 0.72 | DBH (0.38) | DBHHDAC4HDAC2HDAC8HDAC6 | |
| SCHEMBL23250722 | 0.72 | DBH (0.38) | DBHHDAC4HDAC2HDAC8HDAC6 | |
| SCHEMBL23258730 | 0.72 | DBH (0.38) | DBHHDAC4HDAC2HDAC8HDAC6 | |
| SCHEMBL23259207 | 0.71 | DBH (0.37) | DBHMAOAMAOBHDAC4HDAC2 | |
| SCHEMBL23250731 | 0.71 | DBH (0.37) | DBHHDAC4HDAC2HDAC8HDAC6 | |
| SCHEMBL23258704 | 0.71 | DBH (0.37) | DBHHDAC4HDAC2HDAC8HDAC6 | |
| SCHEMBL27307816 | 0.69 | HDAC4 (0.33) | HDAC4HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024073131-A2 | METHOD OF TREATING NEURODEGENERATIVE DISEASES | THE BOARD OF TRUSTEES OF THE UNIVESITY OF ILLINOIS (US) | 2024-04-04 | — | — | WO | disclosed |
| WO-2021076938-A1 | TROPOLONE DERIVATIVES AND TAUTOMERS THEREOF FOR IRON REGULATION IN ANIMALS | Ambys Medicines, Inc. (US) | 2021-04-22 | — | — | WO | disclosed |