Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR3 | P22607 | 12/20 | 0.72 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.68 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.68 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.68 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.65 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.62 |
| ▸ | LCK | P06239 | 7/20 | 0.58 |
| ▸ | JAK2 | O60674 | 2/20 | 0.52 |
| ▸ | ABL1 | P00519 | 2/20 | 0.52 |
| ▸ | INSR | P06213 | 2/20 | 0.52 |
| ▸ | FYN | P06241 | 2/20 | 0.52 |
| ▸ | YES1 | P07947 | 2/20 | 0.52 |
| ▸ | LYN | P07948 | 2/20 | 0.52 |
| ▸ | RET | P07949 | 2/20 | 0.52 |
| ▸ | MET | P08581 | 2/20 | 0.52 |
| ▸ | ROS1 | P08922 | 2/20 | 0.52 |
| ▸ | KIT | P10721 | 2/20 | 0.52 |
| ▸ | SRC | P12931 | 2/20 | 0.52 |
| ▸ | BRAF | P15056 | 2/20 | 0.52 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL374601 | 0.92 | FGFR3 (0.80) | FGFR3CYP3A4CYP2C19CYP2C9CYP1A2 | |
| SCHEMBL374211 | 0.88 | FGFR3 (0.87) | FGFR3CYP3A4CYP2C19CYP2C9CYP1A2 | |
| SCHEMBL581714 | 0.84 | FGFR1 (0.74) | FGFR3CYP3A4CYP2C19CYP2C9CYP1A2 | |
| SCHEMBL374547 | 0.84 | FGFR3 (1.00) | FGFR3CYP3A4CYP2C19CYP2C9CYP1A2 | |
| SCHEMBL374757 | 0.82 | FGFR3 (0.80) | FGFR3CYP3A4CYP2C19CYP2C9CYP1A2 | |
| SCHEMBL374711 | 0.81 | FGFR3 (1.00) | FGFR3CYP3A4CYP2C19CYP2C9CYP1A2 | |
| SCHEMBL19732275 | 0.79 | FGFR1 (0.84) | FGFR3CYP3A4CYP2C19CYP2C9CYP1A2 | |
| SCHEMBL2013490 | 0.79 | FGFR3 (1.00) | FGFR3CYP3A4CYP2C19CYP2C9CYP1A2 | |
| SCHEMBL582750 | 0.77 | FGFR3 (0.80) | FGFR3CYP3A4CYP2C19CYP2C9CYP1A2 | |
| SCHEMBL16659469 | 0.77 | FGFR1 (1.00) | FGFR3FGFR1FGFR2FGFR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761505-B1 | PYRIMIDINE UREA DERIVATIVES AS KINASE INHIBITORS | NOVARTIS AG (CH) | 2011-08-17 | — | — | EP | disclosed |