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SCHEMBL23266265

SCHEMBL23266265

CCn1c(=O)c(OCC(=O)NC)cc2cc(Nc3nc(N4CCC(CN5CCN(c6ccc7c(c6)C(=O)N(C6CCC(=O)NC6=O)C7=O)CC5)CC4)ncc3Cl)ccc21

nearest known ligand 0.49

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ BCL6 P41182 6/20 0.49
▸ NCOR2 Q9Y618 4/20 0.49
▸ MELK Q14680 1/20 0.49
▸ PTK2 Q05397 7/20 0.48
▸ BTK Q06187 2/20 0.48
▸ CRBN Q96SW2 4/20 0.45
▸ AR P10275 3/20 0.45
▸ ALK Q9UM73 2/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31595571 1.00 BCL6 (0.49) BCL6NCOR2MELKPTK2BTK
SCHEMBL23267692 0.96 BCL6 (0.50) BCL6NCOR2MELKPTK2BTK
SCHEMBL31595491 0.95 PTK2 (0.49) BCL6NCOR2MELKPTK2BTK
SCHEMBL23267926 0.95 PTK2 (0.49) BCL6NCOR2MELKPTK2BTK
SCHEMBL23267719 0.95 BCL6 (0.50) BCL6NCOR2MELKPTK2BTK
SCHEMBL31595200 0.94 BCL6 (0.48) BCL6NCOR2MELKPTK2BTK
SCHEMBL23267924 0.94 BCL6 (0.49) BCL6NCOR2MELKPTK2BTK
SCHEMBL23249960 0.94 BCL6 (0.57) BCL6NCOR2MELKPTK2BTK
SCHEMBL23249916 0.94 BCL6 (0.57) BCL6NCOR2MELKPTK2BTK
SCHEMBL29874253 0.94 BCL6 (0.57) BCL6NCOR2MELKPTK2BTK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2021077010-A1 BIFUNCTIONAL MOLECULES CONTAINING AN E3 UBIQUITINE LIGASE BINDING MOIETY LINKED TO A BCL6 TARGETING MOIETY ARVINAS OPERATIONS, INC. (US) 2021-04-22 — — WO disclosed
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