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SCHEMBL23267334

SCHEMBL23267334

Cn1c(=O)n(CCC(C)(C)O)c2cc(Nc3nc(N4CCN(CC5CCN(c6cccc7c6C(=O)N(C6CCC(O)NC6=O)C7=O)CC5)CC4)ncc3Cl)ccc21

nearest known ligand 0.58

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
▸ BCL6 P41182 20/20 0.58
▸ NCOR2 Q9Y618 6/20 0.55
▸ ADRB3 P13945 1/20 0.51
▸ HTR1D P28221 1/20 0.51
▸ ADORA1 P30542 1/20 0.51
▸ OPRM1 P35372 1/20 0.51
▸ SLC6A3 Q01959 1/20 0.51
▸ TMEM97 Q5BJF2 1/20 0.51
▸ HRH3 Q9Y5N1 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23267370 1.00 BCL6 (0.58) BCL6NCOR2ADRB3HTR1DADORA1
SCHEMBL31595331 0.92 BCL6 (0.58) BCL6NCOR2ADRB3HTR1DADORA1
SCHEMBL31595552 0.92 BCL6 (0.58) BCL6NCOR2ADRB3HTR1DADORA1
SCHEMBL23250116 0.82 BCL6 (0.61) BCL6NCOR2ADRB3HTR1DADORA1
SCHEMBL29874314 0.82 BCL6 (0.61) BCL6NCOR2ADRB3HTR1DADORA1
SCHEMBL23267371 0.80 BCL6 (0.56) BCL6NCOR2ADRB3HTR1DADORA1
SCHEMBL31595359 0.80 BCL6 (0.56) BCL6NCOR2ADRB3HTR1DADORA1
SCHEMBL31211517 0.79 BCL6 (0.83) BCL6NCOR2ADRB3HTR1DADORA1
SCHEMBL23357507 0.79 BCL6 (0.83) BCL6NCOR2ADRB3HTR1DADORA1
SCHEMBL23267500 0.77 BCL6 (0.82) BCL6NCOR2ADRB3HTR1DADORA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2021077010-A1 BIFUNCTIONAL MOLECULES CONTAINING AN E3 UBIQUITINE LIGASE BINDING MOIETY LINKED TO A BCL6 TARGETING MOIETY ARVINAS OPERATIONS, INC. (US) 2021-04-22 — — WO disclosed
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