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SCHEMBL23267369

SCHEMBL23267369

CNC(=O)COc1cc2cc(Nc3nc(N4CCC(CCN5CCN(c6ccc7c(c6)C(=O)N(C6CCC(=O)NC6=O)C7=O)CC5)CC4)ncc3Cl)ccc2n(C)c1=O

nearest known ligand 0.57

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ BCL6 P41182 7/20 0.57
▸ NCOR2 Q9Y618 4/20 0.57
▸ MELK Q14680 1/20 0.56
▸ PTK2 Q05397 12/20 0.52
▸ CHRM4 P08173 1/20 0.47
▸ BCL6B Q8N143 1/20 0.47
▸ EGFR P00533 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31595424 1.00 BCL6 (0.57) BCL6NCOR2MELKPTK2CHRM4
SCHEMBL23267933 1.00 BCL6 (0.57) BCL6NCOR2MELKPTK2CHRM4
SCHEMBL31595656 1.00 BCL6 (0.57) BCL6NCOR2MELKPTK2CHRM4
SCHEMBL23267314 0.96 BCL6 (0.60) BCL6NCOR2MELKPTK2CHRM4
SCHEMBL23249916 0.96 BCL6 (0.57) BCL6NCOR2MELKPTK2CHRM4
SCHEMBL29874253 0.96 BCL6 (0.57) BCL6NCOR2MELKPTK2CHRM4
SCHEMBL23249960 0.96 BCL6 (0.57) BCL6NCOR2MELKPTK2CHRM4
SCHEMBL29874152 0.96 BCL6 (0.57) BCL6NCOR2MELKPTK2CHRM4
SCHEMBL31595440 0.95 BCL6 (0.50) BCL6NCOR2MELKPTK2EGFR
SCHEMBL23267676 0.95 BCL6 (0.50) BCL6NCOR2MELKPTK2EGFR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2021077010-A1 BIFUNCTIONAL MOLECULES CONTAINING AN E3 UBIQUITINE LIGASE BINDING MOIETY LINKED TO A BCL6 TARGETING MOIETY ARVINAS OPERATIONS, INC. (US) 2021-04-22 — — WO disclosed
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