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SCHEMBL23267717

SCHEMBL23267717

CCn1c(=O)c(OCC(=O)NC)cc2cc(Nc3nc(N4CCC(OC5CCN(c6cccc7c6C(=O)N(C6CCC(=O)NC6=O)C7=O)CC5)CC4)ncc3Cl)ccc21

nearest known ligand 0.48

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
▸ BCL6 P41182 7/20 0.48
▸ NCOR2 Q9Y618 4/20 0.48
▸ MELK Q14680 1/20 0.47
▸ PTK2 Q05397 11/20 0.43
▸ ALK Q9UM73 1/20 0.42
▸ CHRM4 P08173 1/20 0.42
▸ BCL6B Q8N143 1/20 0.42
▸ HPGDS O60760 1/20 0.42
▸ CRBN Q96SW2 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31595523 1.00 BCL6 (0.48) BCL6NCOR2MELKPTK2ALK
SCHEMBL31595535 0.94 BCL6 (0.46) BCL6NCOR2MELKPTK2ALK
SCHEMBL31595375 0.94 BCL6 (0.46) BCL6NCOR2MELKPTK2ALK
SCHEMBL31595230 0.94 BCL6 (0.56) BCL6NCOR2MELKPTK2CHRM4
SCHEMBL23267908 0.94 BCL6 (0.56) BCL6NCOR2MELKPTK2CHRM4
SCHEMBL23266802 0.93 BCL6 (0.47) BCL6NCOR2MELKPTK2
SCHEMBL31595238 0.93 BCL6 (0.47) BCL6NCOR2MELKPTK2
SCHEMBL23267390 0.92 BCL6 (0.48) BCL6NCOR2MELKPTK2ALK
SCHEMBL31595540 0.92 BCL6 (0.48) BCL6NCOR2MELKPTK2ALK
SCHEMBL23267691 0.92 BCL6 (0.46) BCL6NCOR2MELKPTK2ALK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2021077010-A1 BIFUNCTIONAL MOLECULES CONTAINING AN E3 UBIQUITINE LIGASE BINDING MOIETY LINKED TO A BCL6 TARGETING MOIETY ARVINAS OPERATIONS, INC. (US) 2021-04-22 — — WO disclosed
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