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SCHEMBL23267722

SCHEMBL23267722

CNC(=O)CCN1Cc2cc(Nc3nc(N4CCN(CC5CCN(c6ccc7c(c6)C(=O)N(C6CCC(=O)NC6=O)C7=O)CC5)CC4)ncc3Cl)ccc2CC1=O

nearest known ligand 0.53

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
▸ CRBN Q96SW2 5/20 0.53
▸ BTK Q06187 2/20 0.53
▸ PTK2 Q05397 12/20 0.49
▸ AR P10275 2/20 0.46
▸ ALK Q9UM73 2/20 0.43
▸ IRAK1 P51617 1/20 0.43
▸ IRAK4 Q9NWZ3 1/20 0.43
▸ IRAK3 Q9Y616 1/20 0.43
▸ ITK Q08881 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31595461 1.00 CRBN (0.53) CRBNBTKPTK2ARALK
SCHEMBL23267675 0.85 PTK2 (0.49) CRBNBTKPTK2AR
SCHEMBL31595777 0.84 CRBN (0.53) CRBNBTKPTK2ARALK
SCHEMBL23268167 0.84 PTK2 (0.49) CRBNBTKPTK2AR
SCHEMBL23249916 0.83 BCL6 (0.57) CRBNBTKPTK2ARALK
SCHEMBL29874253 0.83 BCL6 (0.57) CRBNBTKPTK2ARALK
SCHEMBL23249960 0.83 BCL6 (0.57) CRBNBTKPTK2ARALK
SCHEMBL29874152 0.83 BCL6 (0.57) CRBNBTKPTK2ARALK
SCHEMBL31595205 0.83 PTK2 (0.50) CRBNBTKPTK2AR
SCHEMBL23267394 0.83 PTK2 (0.50) CRBNBTKPTK2AR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2021077010-A1 BIFUNCTIONAL MOLECULES CONTAINING AN E3 UBIQUITINE LIGASE BINDING MOIETY LINKED TO A BCL6 TARGETING MOIETY ARVINAS OPERATIONS, INC. (US) 2021-04-22 — — WO disclosed
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