SCHEMBL23269752

SCHEMBL23269752

Cc1cc(N)nc(C)c1CNC(=O)c1ccnc(Cc2cccc3ccc(C(N)=O)nc23)c1

nearest known ligand 0.70

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
KLKB1 P03952 19/20 0.70
MAP4K1 Q92918 16/20 0.70

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23269755 0.88 KLKB1 (0.70) KLKB1MAP4K1
SCHEMBL23269766 0.83 KLKB1 (0.64) KLKB1MAP4K1
SCHEMBL17442564 0.82 KLKB1 (1.00) KLKB1MAP4K1
SCHEMBL23269759 0.81 KLKB1 (0.55) KLKB1MAP4K1
SCHEMBL23269754 0.80 KLKB1 (0.58) KLKB1MAP4K1
SCHEMBL28374126 0.78 KLKB1 (0.65) KLKB1MAP4K1
SCHEMBL23269764 0.78 KLKB1 (0.65) KLKB1MAP4K1
SCHEMBL23269773 0.77 KLKB1 (0.64) KLKB1MAP4K1
SCHEMBL23269770 0.76 KLKB1 (0.66) KLKB1MAP4K1
SCHEMBL18370128 0.75 KLKB1 (0.68) KLKB1MAP4K1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3169325-B1 THERAPEUTIC INHIBITORY COMPOUNDS ATTUNE PHARMACEUTICALS INC (US) 2021-04-28 EP claimed