Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 2/20 | 0.49 |
| ▸ | AURKA | O14965 | 6/20 | 0.49 |
| ▸ | EGFR | P00533 | 3/20 | 0.48 |
| ▸ | ABL1 | P00519 | 2/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.48 |
| ▸ | KIT | P10721 | 1/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.48 |
| ▸ | SRC | P12931 | 1/20 | 0.48 |
| ▸ | BRAF | P15056 | 1/20 | 0.48 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.48 |
| ▸ | TEK | Q02763 | 1/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
| ▸ | LCK | P06239 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | NOX1 | Q9Y5S8 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | HTR2B | P41595 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL374526 | 0.81 | EGFR (0.69) | KDREGFRABL1PDGFRBKIT | |
| SCHEMBL6978712 | 0.73 | MEN1 (0.58) | AURKAEGFRLCKMEN1KMT2A | |
| SCHEMBL374331 | 0.72 | LCK (0.81) | LCK | |
| SCHEMBL28606997 | 0.71 | KMT2A (0.44) | KDREGFRABL1PDGFRBKIT | |
| SCHEMBL374872 | 0.69 | EGFR (0.54) | KDREGFRABL1PDGFRBKIT | |
| SCHEMBL27838991 | 0.66 | CA1 (0.49) | AURKAKITFGFR1BRAFMEN1 | |
| SCHEMBL10221479 | 0.66 | MEN1 (0.73) | MEN1KMT2ANPC1NOX1RAB9A | |
| SCHEMBL15492045 | 0.66 | AURKA (1.00) | AURKAAURKB | |
| SCHEMBL6978702 | 0.66 | IGF1R (0.64) | KDRAURKAEGFRFGFR1SRC | |
| SCHEMBL27819551 | 0.66 | SYK (0.69) | KDRAURKAEGFRABL1FGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761505-B1 | PYRIMIDINE UREA DERIVATIVES AS KINASE INHIBITORS | NOVARTIS AG (CH) | 2011-08-17 | — | — | EP | disclosed |