Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | PDE1C | Q14123 | 6/20 | 0.39 |
| ▸ | PDE1B | Q01064 | 6/20 | 0.39 |
| ▸ | PDE1A | P54750 | 5/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | CAPN1 | P07384 | 4/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | ACE | P12821 | 1/20 | 0.33 |
| ▸ | IGF1R | P08069 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2327637 | 1.00 | CNR2 (0.40) | CNR2PDE1CPDE1BPDE1AHTT | |
| SCHEMBL2327527 | 0.90 | CNR2 (0.41) | CNR2PDE1CPDE1BPDE1ACAPN1 | |
| SCHEMBL2327535 | 0.90 | CNR2 (0.41) | CNR2PDE1CPDE1BPDE1ACAPN1 | |
| SCHEMBL2321328 | 0.76 | CNR2 (0.39) | CNR2IGF1R | |
| SCHEMBL2321334 | 0.76 | CNR2 (0.39) | CNR2IGF1R | |
| SCHEMBL593254 | 0.75 | PDE1C (0.38) | PDE1CPDE1BPDE1AHTTIGF1R | |
| SCHEMBL593256 | 0.75 | PDE1C (0.38) | PDE1CPDE1BPDE1AHTTIGF1R | |
| SCHEMBL593236 | 0.75 | SMN1; SMN2 (0.50) | HTT | |
| SCHEMBL1129460 | 0.75 | TNK2 (0.57) | IGF1R | |
| SCHEMBL3179988 | 0.74 | PDE1C (0.40) | CNR2PDE1CPDE1BPDE1AIGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8658794-B2 | 8-methyl-1-phenyl-imidazol[1,5-a]pyrazine compounds as Lck inhibitors and uses thereof | MERCK SHARP & DOHME B.V. (NL) | 2014-02-25 | — | — | US | disclosed |
| US-20120309966-A1 | 8-METHYL-1-PHENYL-IMIDAZOL[1,5-A]PYRAZINE COMPOUNDS | N.V. ORGANON (NL) | 2012-12-06 | — | — | US | disclosed |
| WO-2011095556-A1 | 8-METHYL-1-PHENYL-IMIDAZOL[1,5-A]PYRAZINE COMPOUNDS | N.V. ORGANON (NL) | 2011-08-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120309966-A1 | 8-METHYL-1-PHENYL-IMIDAZOL[1,5-A]PYRAZINE COMPOUNDS | LCK, ZAP70, FYN | CNR2 2049/4885PDE1C 951/4885PDE1B 900/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.