Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 20/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19045318 | 1.00 | IRAK4 (0.72) | IRAK4 | |
| SCHEMBL19045673 | 0.94 | IRAK4 (0.73) | IRAK4 | |
| SCHEMBL19045849 | 0.92 | IRAK4 (0.70) | IRAK4 | |
| SCHEMBL19045646 | 0.88 | IRAK4 (0.74) | IRAK4 | |
| SCHEMBL19046072 | 0.87 | IRAK4 (0.73) | IRAK4 | |
| SCHEMBL23278035 | 0.87 | IRAK4 (0.71) | IRAK4 | |
| SCHEMBL19045667 | 0.87 | IRAK4 (0.75) | IRAK4 | |
| SCHEMBL19046158 | 0.86 | IRAK4 (0.75) | IRAK4 | |
| SCHEMBL23277887 | 0.86 | IRAK4 (0.73) | IRAK4 | |
| SCHEMBL19045930 | 0.86 | IRAK4 (0.75) | IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10988478-B1 | Pyrazolo[1,5a]pyrimidine derivatives as IRAK4 modulators | GENENTECH, INC. (US) | 2021-04-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10988478-B1 | Pyrazolo[1,5a]pyrimidine derivatives as IRAK4 modulators | IRAK1, IRAK4, IRAK2 | IRAK4 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.