Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | XDH | P47989 | 1/20 | 0.32 |
| ▸ | GFER | P55789 | 1/20 | 0.32 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.32 |
| ▸ | RELA | Q04206 | 1/20 | 0.32 |
| ▸ | FUT7 | Q11130 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12491666 | 0.90 | KCNH2 (0.33) | ALDH1A1TSHRKCNH2NPSR1KDM4E | |
| SCHEMBL16785727 | 0.85 | KCNH2 (0.33) | KCNH2NPSR1KDM4EPOLBTDP1 | |
| SCHEMBL1353549 | 0.80 | GABRR1 (0.31) | — | |
| SCHEMBL23048514 | 0.80 | GABRR1 (0.31) | — | |
| SCHEMBL13720079 | 0.79 | KCNH2 (0.35) | TSHRKCNH2NPSR1KDM4EPOLB | |
| SCHEMBL11886079 | 0.79 | KCNH2 (0.35) | TSHRKCNH2NPSR1KDM4EPOLB | |
| SCHEMBL17683049 | 0.77 | KCNH2 (0.34) | TSHRKCNH2KDM4EPOLBTDP1 | |
| SCHEMBL805476 | 0.77 | GABRR1 (0.37) | ALDH1A1TSHRKCNH2KDM4EPOLB | |
| SCHEMBL22803044 | 0.76 | PPARG (0.31) | ALDH1A1KDM4EGAAKMT2A | |
| SCHEMBL11886388 | 0.76 | KCNH2 (0.36) | KCNH2KDM4EPOLBTDP1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3189041-B1 | TETRAHYDROISOQUINOLINE DERIVED PRMT5-INHIBITORS | CTXT PTY LTD (AU) | 2021-04-28 | — | — | EP | disclosed |