Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 11/20 | 0.48 |
| ▸ | AR | P10275 | 6/20 | 0.48 |
| ▸ | BTK | Q06187 | 4/20 | 0.46 |
| ▸ | HPGDS | O60760 | 3/20 | 0.42 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.42 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.42 |
| ▸ | IRAK3 | Q9Y616 | 1/20 | 0.42 |
| ▸ | ITK | Q08881 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | PLK4 | O00444 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24030050 | 0.93 | CRBN (0.55) | CRBNARBTKHPGDSIRAK1 | |
| SCHEMBL23129054 | 0.91 | CRBN (0.55) | CRBNARBTKHPGDSIRAK1 | |
| SCHEMBL24030221 | 0.85 | CRBN (0.55) | CRBNARBTKHPGDSIRAK1 | |
| SCHEMBL27113664 | 0.85 | AR (0.64) | CRBNAR | |
| SCHEMBL25899965 | 0.84 | CRBN (0.63) | CRBNARBTKHPGDSIRAK1 | |
| SCHEMBL23171819 | 0.84 | CRBN (0.63) | CRBNARBTKHPGDSIRAK1 | |
| SCHEMBL24030246 | 0.84 | BTK (0.54) | CRBNARBTKHPGDSIRAK1 | |
| SCHEMBL25691418 | 0.84 | CRBN (0.47) | CRBNARBTKHPGDSIRAK1 | |
| SCHEMBL23129212 | 0.83 | CRBN (0.60) | CRBNARBTKHPGDSIRAK1 | |
| SCHEMBL24506843 | 0.82 | BTK (0.54) | CRBNARBTKHPGDSIRAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021081108-A1 | METHODS OF TREATING PROSTATE CANCER | ARVINAS OPERATIONS, INC. (US) | 2021-04-29 | — | — | WO | disclosed |