Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK12 | Q9NYV4 | 16/20 | 0.65 |
| ▸ | CCNK | O75909 | 15/20 | 0.48 |
| ▸ | CDK13 | Q14004 | 1/20 | 0.47 |
| ▸ | IDH1 | O75874 | 1/20 | 0.46 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.46 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28550159 | 1.00 | CDK12 (0.65) | CDK12CCNKCDK13IDH1USP30 | |
| SCHEMBL22895468 | 1.00 | CDK12 (0.65) | CDK12CCNKCDK13IDH1USP30 | |
| SCHEMBL22895930 | 0.90 | CDK12 (0.55) | CDK12CCNKCDK13USP30 | |
| SCHEMBL23292283 | 0.90 | CDK12 (0.55) | CDK12CCNKCDK13USP30 | |
| SCHEMBL22895412 | 0.88 | CDK12 (0.51) | CDK12CCNKCDK13USP30 | |
| SCHEMBL23292179 | 0.88 | CDK12 (0.51) | CDK12CCNKCDK13USP30 | |
| SCHEMBL28551795 | 0.88 | CDK12 (0.51) | CDK12CCNKCDK13USP30 | |
| SCHEMBL23292344 | 0.88 | CCNK (0.61) | CDK12CCNKCDK13 | |
| SCHEMBL22895516 | 0.88 | CCNK (0.61) | CDK12CCNKCDK13 | |
| SCHEMBL23325385 | 0.88 | CCNK (0.61) | CDK12CCNKCDK13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3813819-A1 | INHIBITORS OF CYCLIN-DEPENDENT KINASES | Kinnate Biopharma Inc. (US) | 2021-05-05 | — | — | EP | disclosed |