Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.53 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.50 |
| ▸ | SRC | P12931 | 3/20 | 0.50 |
| ▸ | ABL1 | P00519 | 1/20 | 0.50 |
| ▸ | EGFR | P00533 | 1/20 | 0.50 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.50 |
| ▸ | KIT | P10721 | 1/20 | 0.50 |
| ▸ | BRAF | P15056 | 1/20 | 0.50 |
| ▸ | KDR | P35968 | 1/20 | 0.50 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.50 |
| ▸ | TEK | Q02763 | 1/20 | 0.50 |
| ▸ | AURKA | O14965 | 2/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 6/20 | 0.44 |
| ▸ | CDK4 | P11802 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL379607 | 0.89 | EGFR (0.64) | HRH3FGFR1SRCABL1EGFR | |
| SCHEMBL374607 | 0.84 | EGFR (0.70) | HRH3FGFR1SRCABL1EGFR | |
| SCHEMBL374215 | 0.78 | FGFR1 (0.74) | HRH3FGFR1SRCABL1EGFR | |
| SCHEMBL374612 | 0.73 | SRC (0.81) | HRH3FGFR1SRCABL1EGFR | |
| SCHEMBL374262 | 0.72 | FGFR1 (0.91) | HRH3FGFR1SRCABL1EGFR | |
| SCHEMBL1518686 | 0.71 | MAPK8 (0.59) | EGFRMEN1MAPTKMT2A | |
| SCHEMBL374671 | 0.69 | EPHX2 (0.59) | ABL1EGFRBRAFKDRAURKA | |
| SCHEMBL374510 | 0.67 | EPHX2 (0.52) | SRCABL1EGFRBRAFKDR | |
| SCHEMBL374634 | 0.67 | FGFR1 (1.00) | HRH3FGFR1SRCABL1EGFR | |
| SCHEMBL6982577 | 0.67 | KMT2A (0.66) | RAB9AALDH1A1HTTMEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761505-B1 | PYRIMIDINE UREA DERIVATIVES AS KINASE INHIBITORS | NOVARTIS AG (CH) | 2011-08-17 | — | — | EP | disclosed |