Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 4/20 | 0.66 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.66 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.66 |
| ▸ | HTT | P42858 | 3/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23297620 | 0.93 | HTT (0.57) | MAOBADORA2AADORA1HTTCYP1A2 | |
| SCHEMBL23297637 | 0.92 | HTT (0.56) | MAOBADORA2AADORA1HTTCYP1A2 | |
| SCHEMBL23297598 | 0.92 | HTT (0.56) | MAOBADORA2AADORA1HTTCYP1A2 | |
| SCHEMBL23297564 | 0.92 | HTT (0.58) | MAOBADORA2AADORA1HTTCYP1A2 | |
| SCHEMBL23297748 | 0.91 | HTT (0.55) | MAOBADORA2AADORA1HTTCYP1A2 | |
| SCHEMBL23297609 | 0.90 | ADORA2A (0.54) | MAOBADORA2AADORA1HTTCYP1A2 | |
| SCHEMBL20680543 | 0.88 | ADORA2A (0.53) | MAOBADORA2AADORA1HTTCYP1A2 | |
| SCHEMBL23297759 | 0.88 | HTT (0.54) | MAOBADORA2AADORA1HTTCYP1A2 | |
| SCHEMBL23297630 | 0.86 | ADORA2A (0.54) | MAOBADORA2AADORA1HTTCYP1A2 | |
| SCHEMBL23297562 | 0.86 | HTT (0.52) | MAOBADORA2AADORA1HTTCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210128566-A1 | NOVEL FUNCTIONALIZED PURINE-2,6-DIONES AND THEIR USE IN MEDICINE | THOMAS HELLEDAYS STIFTELSE FÖR MEDICINSK FORSKNING (SE) | 2021-05-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210128566-A1 | NOVEL FUNCTIONALIZED PURINE-2,6-DIONES AND THEIR USE IN MEDICINE | ADORA2A, HPRT1, PNP | MAOB 970/4885ADORA2A 1/4885ADORA1 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.