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SCHEMBL23298710

SCHEMBL23298710

CN1CCN(CC[C@H](CSc2ccccc2)Nc2ccc(S(=O)(=O)NC(=O)c3ccc(NCCNCC4=C(c5ccc(Cl)cc5)CCC(C)(C)C4)cc3)cc2S(=O)(=O)C(F)(F)F)CC1

nearest known ligand 0.74

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ BCL2L1 Q07817 17/20 0.74
▸ BCL2 P10415 13/20 0.74
▸ BAD Q92934 4/20 0.74
▸ BCL2L2 Q92843 2/20 0.74
▸ BCL2L11 O43521 1/20 0.74
▸ CYP2C9 P11712 1/20 0.74
▸ MCL1 Q07820 1/20 0.74
▸ ASPH Q12797 1/20 0.74

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23298660 0.96 BCL2L1 (0.73) BCL2L1BCL2BADBCL2L2BCL2L11
SCHEMBL19425452 0.95 BCL2L1 (0.80) BCL2L1BCL2BADBCL2L2BCL2L11
SCHEMBL19425319 0.94 BCL2L1 (0.77) BCL2L1BCL2BADBCL2L2BCL2L11
SCHEMBL19425561 0.93 BCL2L1 (0.69) BCL2L1BCL2BADBCL2L2BCL2L11
SCHEMBL19425349 0.93 BCL2L1 (0.75) BCL2L1BCL2BADBCL2L2BCL2L11
SCHEMBL19425368 0.92 BCL2 (0.67) BCL2L1BCL2BADBCL2L2BCL2L11
SCHEMBL19425570 0.92 BCL2L1 (0.76) BCL2L1BCL2BADBCL2L2BCL2L11
SCHEMBL19425405 0.92 BCL2L1 (0.76) BCL2L1BCL2BADBCL2L2BCL2L11
SCHEMBL19425353 0.91 BCL2L1 (0.65) BCL2L1BCL2BADBCL2L2BCL2L11
SCHEMBL19425409 0.91 BCL2 (0.65) BCL2L1BCL2BADBCL2L2BCL2L11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2021078301-A1 PROTEIN DEGRADING AGENT AND USE THEREOF IN TREATMENT OF DISEASES 上海科技大学 2021-04-29 — — WO disclosed
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