Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.41 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.41 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.41 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.41 |
| ▸ | GBA1 | P04062 | 1/20 | 0.39 |
| ▸ | CKS1B | P61024 | 2/20 | 0.36 |
| ▸ | SKP1 | P63208 | 2/20 | 0.36 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.36 |
| ▸ | ACACB | O00763 | 1/20 | 0.36 |
| ▸ | ACACA | Q13085 | 1/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 5/20 | 0.35 |
| ▸ | TP53 | P04637 | 4/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | KHK | P50053 | 1/20 | 0.35 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30260122 | 0.94 | GBA1 (0.43) | GBA1CKS1BSKP1SKP2MTNR1B | |
| SCHEMBL23684218 | 0.94 | GBA1 (0.43) | GBA1CKS1BSKP1SKP2MTNR1B | |
| SCHEMBL23329785 | 0.81 | GBA1 (0.43) | GBA1CKS1BSKP1SKP2MTNR1B | |
| SCHEMBL23304371 | 0.81 | GBA1 (0.43) | GBA1CKS1BSKP1SKP2MAPT | |
| SCHEMBL23304383 | 0.80 | NPC1 (0.41) | GBA1CKS1BSKP1SKP2MAPT | |
| SCHEMBL23304453 | 0.80 | GBA1 (0.35) | GBA1CKS1BSKP1SKP2MTNR1B | |
| SCHEMBL23304587 | 0.79 | HRH4 (0.41) | MAPTTP53 | |
| SCHEMBL23684405 | 0.78 | MAP4K4 (0.39) | GBA1CKS1BSKP1SKP2MAPT | |
| SCHEMBL23304303 | 0.77 | HTR2A (0.40) | GBA1CKS1BSKP1SKP2MAPT | |
| SCHEMBL30260181 | 0.77 | HTR2A (0.40) | GBA1CKS1BSKP1SKP2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021086879-A1 | COMPOUNDS AND METHODS OF USE | TANGO THERAPEUTICS, INC. (US) | 2021-05-06 | — | — | WO | disclosed |