Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 3/20 | 0.49 |
| ▸ | CCR5 | P51681 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 10/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 9/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2022161 | 0.92 | GRM2 (0.51) | GRM2CCR5ALDH1A1HCRTR1HCRTR2 | |
| SCHEMBL2021868 | 0.89 | GRM2 (0.51) | GRM2CCR5ALDH1A1HCRTR1HCRTR2 | |
| SCHEMBL2023195 | 0.89 | GRM2 (0.49) | GRM2CCR5ALDH1A1HCRTR1HCRTR2 | |
| SCHEMBL2021120 | 0.89 | GRM2 (0.49) | GRM2CCR5ALDH1A1HCRTR1HCRTR2 | |
| SCHEMBL2022258 | 0.89 | GRM2 (0.51) | GRM2CCR5ALDH1A1HCRTR1HCRTR2 | |
| SCHEMBL2027898 | 0.88 | GRM2 (0.48) | GRM2CCR5ALDH1A1HCRTR1HCRTR2 | |
| SCHEMBL2021364 | 0.88 | GRM2 (0.50) | GRM2CCR5ALDH1A1HCRTR1HCRTR2 | |
| SCHEMBL2026779 | 0.87 | GRM2 (0.57) | GRM2CCR5ALDH1A1HCRTR1HCRTR2 | |
| SCHEMBL8271236 | 0.87 | GRM2 (0.51) | GRM2CCR5ALDH1A1TSHRCHRM4 | |
| SCHEMBL1002674 | 0.87 | GRM2 (0.51) | GRM2CCR5ALDH1A1TSHRCHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2357169-A1 | Isoindolone compounds and their use as metabotropic glutamate receptor potentiators | AstraZeneca AB (SE) | 2011-08-17 | — | — | EP | disclosed |