Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 2/20 | 0.48 |
| ▸ | HCRTR1 | O43613 | 10/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 10/20 | 0.34 |
| ▸ | HTR2C | P28335 | 2/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | ACACB | O00763 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2025534 | 0.83 | GRM2 (0.62) | GRM2HCRTR1HCRTR2HTR2CALDH1A1 | |
| SCHEMBL2028589 | 0.81 | GRM2 (0.53) | GRM2HCRTR1HCRTR2HTR2CALDH1A1 | |
| SCHEMBL2022488 | 0.80 | GRM2 (0.51) | GRM2HCRTR1HCRTR2HRH3ALDH1A1 | |
| SCHEMBL2028720 | 0.79 | GRM2 (0.53) | GRM2HCRTR1HCRTR2CHRM4ALDH1A1 | |
| SCHEMBL2022288 | 0.77 | GRM2 (0.47) | GRM2HCRTR1HCRTR2CHRM4ALDH1A1 | |
| SCHEMBL8271956 | 0.77 | GRM2 (0.47) | GRM2HCRTR1HCRTR2CHRM4ALDH1A1 | |
| SCHEMBL2028083 | 0.76 | GRM2 (0.47) | GRM2HCRTR1HCRTR2HRH3CHRM4 | |
| SCHEMBL2027899 | 0.76 | GRM2 (0.53) | GRM2HCRTR1HCRTR2HTR2CALDH1A1 | |
| SCHEMBL2022164 | 0.76 | GRM2 (0.54) | GRM2HCRTR1HCRTR2HTR2CALDH1A1 | |
| SCHEMBL2023238 | 0.76 | GRM2 (0.54) | GRM2CHRM4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2357169-A1 | Isoindolone compounds and their use as metabotropic glutamate receptor potentiators | AstraZeneca AB (SE) | 2011-08-17 | — | — | EP | disclosed |