Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 9/20 | 0.45 |
| ▸ | PDE4A | P27815 | 7/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.37 |
| ▸ | APEX1 | P27695 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1553629 | 0.80 | PDE4D (0.65) | PDE4DPDE4APDE4BPDE4CMAPT | |
| Hydrochloric Acid SCHEMBL8573929 | 0.79 | PDE4D (0.64) | PDE4DPDE4APDE4BPDE4CAPEX1 | |
| SCHEMBL2335278 | 0.75 | PBK (0.48) | PDE4DPDE4APDE4BPDE4CSLC6A3 | |
| SCHEMBL8573926 | 0.72 | PDE4A (0.67) | PDE4DPDE4APDE4BPDE4CKMT2A | |
| SCHEMBL1554931 | 0.71 | PDE4D (0.65) | PDE4DPDE4APDE4BPDE4CMAPT | |
| SCHEMBL1553952 | 0.70 | PDE4D (0.67) | PDE4DPDE4APDE4BPDE4CMAPT | |
| Hydrochloric Acid SCHEMBL8575508 | 0.70 | PDE4D (0.64) | PDE4DPDE4APDE4BPDE4CMAPT | |
| SCHEMBL2332188 | 0.66 | PBK (0.52) | PDE4DPDE4APDE4BPDE4CSLC6A3 | |
| SCHEMBL8575498 | 0.65 | PDE4A (0.67) | PDE4DPDE4APDE4BPDE4CKMT2A | |
| SCHEMBL8605672 | 0.64 | PDE4A (0.54) | PDE4DPDE4APDE4BPDE4CKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2358365-A1 | GLYCOGEN SYNTHASE KINASE-3 BETA INHIBITORS CONTAINING 7-HYDROXY-BENZOIMIDAZOLE-4-YL-METHANONE DERIVATIVES | Oncotherapy Science, Inc. (JP) | 2011-08-24 | — | — | EP | disclosed |
| WO-2010058512-A1 | GLYCOGEN SYNTHASE KINASE-3 BETA INHIBITORS CONTAINING 7-HYDROXY-BENZOIMIDAZOLE-4-YL-METHANONE DERIVATIVES | ONCOTHERAPY SCIENCE, INC. (JP) | 2010-05-27 | — | — | WO | disclosed |