Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 7/20 | 0.79 |
| ▸ | PDE4A | P27815 | 14/20 | 0.74 |
| ▸ | PDE4B | Q07343 | 14/20 | 0.74 |
| ▸ | PDE4C | Q08493 | 14/20 | 0.74 |
| ▸ | PDE4D | Q08499 | 14/20 | 0.74 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL717406 | 0.88 | KCNH2 (1.00) | KCNH2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL12995884 | 0.88 | KCNH2 (0.81) | KCNH2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL1566354 | 0.86 | KCNH2 (0.77) | KCNH2PDE4APDE4BPDE4CPDE4D | |
| Mk-0873 SCHEMBL29372259 | 0.85 | PDE4A (1.00) | KCNH2PDE4APDE4BPDE4CPDE4D | |
| Mk-0873 SCHEMBL4950462 | 0.85 | PDE4A (1.00) | KCNH2PDE4APDE4BPDE4CPDE4D | |
| Mk-0873 SCHEMBL29496418 | 0.85 | PDE4A (1.00) | KCNH2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL1566248 | 0.85 | KCNH2 (0.76) | KCNH2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8237027 | 0.85 | KCNH2 (0.77) | KCNH2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL12198465 | 0.84 | PDE4A (0.84) | KCNH2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL1566139 | 0.82 | KCNH2 (0.71) | KCNH2PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2536715-A1 | PREPARATION OF LAMIVUDINE FORM I | Merck Sharp & Dohme Corp. (US) | 2012-12-26 | — | — | EP | disclosed |
| WO-2011100381-A1 | PREPARATION OF LAMIVUDINE FORM I | MERCK SHARP & DOHME CORP. (US) | 2011-08-18 | — | — | WO | disclosed |