SCHEMBL2331376

SCHEMBL2331376

CC(c1ccccc1)N1CC2(CN(C(=O)O)C2)C1

nearest known ligand 0.50

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CYP2D6 P10635 14/20 0.50
CYP3A4 P08684 12/20 0.48
ALDH1A1 P00352 5/20 0.48
CYP1A2 P05177 8/20 0.46
TSHR P16473 7/20 0.46
OPRM1 P35372 1/20 0.45
OPRD1 P41143 1/20 0.45
OPRK1 P41145 1/20 0.45
OPRL1 P41146 1/20 0.45
CYP2C9 P11712 9/20 0.45
CYP2C19 P33261 6/20 0.45
MC4R P32245 1/20 0.45
USP2 O75604 6/20 0.44
HIF1A Q16665 3/20 0.43
KMT2A Q03164 2/20 0.41
MEN1 O00255 1/20 0.41
MAPK1 P28482 1/20 0.40
RECQL P46063 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2337932 0.86 CYP2D6 (0.65) CYP2D6CYP3A4ALDH1A1CYP1A2OPRM1
Hydrochloric Acid SCHEMBL2330314 0.84 CYP2D6 (0.63) CYP2D6CYP3A4ALDH1A1CYP1A2OPRM1
SCHEMBL2333908 0.82 ATM (0.45) CYP2D6CYP3A4ALDH1A1CYP1A2TSHR
SCHEMBL27571753 0.78 CYP2D6 (0.71) CYP2D6ALDH1A1OPRM1OPRD1OPRK1
SCHEMBL10565433 0.78 CYP2D6 (0.55) CYP2D6CYP3A4ALDH1A1TSHROPRM1
SCHEMBL9009194 0.75 CYP2D6 (0.55) CYP2D6CYP3A4ALDH1A1CYP1A2OPRM1
Hydrochloric Acid SCHEMBL2334345 0.73 CYP2D6 (0.53) CYP2D6CYP3A4ALDH1A1CYP1A2OPRM1
SCHEMBL10568119 0.71 CYP2D6 (0.55) CYP2D6ALDH1A1OPRM1OPRD1OPRK1
SCHEMBL31493496 0.71 CYP2D6 (0.55) CYP2D6CYP3A4ALDH1A1CYP1A2TSHR
SCHEMBL19049380 0.70 KMT2A (0.73) CYP2D6CYP3A4ALDH1A1CYP1A2TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2358677-A1 NAPHTHYLACETIC ACIDS USED AS CRTH2 ANTAGONISTS OR PARTIAL AGONISTS F. Hoffmann-La Roche AG (CH) 2011-08-24 EP disclosed
WO-2010055006-A1 NAPHTHYLACETIC ACIDS USED AS CRTH2 ANTAGONISTS OR PARTIAL AGONISTS F. HOFFMANN-LA ROCHE AG (CH) 2010-05-20 WO disclosed