Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 4/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 8/20 | 0.32 |
| ▸ | DYRK2 | Q92630 | 8/20 | 0.32 |
| ▸ | DYRK3 | O43781 | 7/20 | 0.32 |
| ▸ | DYRK1B | Q9Y463 | 7/20 | 0.32 |
| ▸ | CDK5 | Q00535 | 5/20 | 0.32 |
| ▸ | CDK5R1 | Q15078 | 5/20 | 0.32 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.32 |
| ▸ | CDK2 | P24941 | 4/20 | 0.32 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.32 |
| ▸ | CDK9 | P50750 | 3/20 | 0.32 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.31 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5060984 | 0.80 | TNF (0.36) | TNFADORA2ADYRK1ADYRK2DYRK3 | |
| SCHEMBL2360104 | 0.71 | TSHR (0.56) | TNF | |
| SCHEMBL13110756 | 0.70 | TNF (0.49) | TNFADORA2ADYRK1ADYRK2DYRK3 | |
| SCHEMBL16010635 | 0.69 | TNF (0.44) | TNFADORA2ADYRK1ADYRK2DYRK3 | |
| SCHEMBL3453191 | 0.65 | TNF (0.46) | TNFDYRK1ADYRK2DYRK3DYRK1B | |
| SCHEMBL16554675 | 0.65 | TNF (0.50) | TNFADORA2ADYRK1ADYRK2DYRK3 | |
| SCHEMBL3452648 | 0.65 | TNF (0.43) | TNFADORA2ADYRK1ADYRK2DYRK3 | |
| SCHEMBL1163165 | 0.65 | DYRK1A (0.49) | TNFDYRK1ADYRK2DYRK3DYRK1B | |
| SCHEMBL18774038 | 0.64 | TNF (0.46) | TNFADORA2ADYRK1ADYRK2DYRK3 | |
| SCHEMBL28741961 | 0.62 | TNF (0.47) | TNFADORA2ADYRK1ADYRK2DYRK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2533645-A1 | METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION | The Johns Hopkins University (US) | 2012-12-19 | — | — | EP | disclosed |
| WO-2011100373-A1 | METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION | THE JOHNS HOPKINS UNIVERSITY (US) | 2011-08-18 | — | — | WO | disclosed |