Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 4/20 | 0.50 |
| ▸ | MME | P08473 | 9/20 | 0.47 |
| ▸ | ACE | P12821 | 6/20 | 0.47 |
| ▸ | CPA1 | P15085 | 5/20 | 0.47 |
| ▸ | ACE2 | Q9BYF1 | 5/20 | 0.47 |
| ▸ | CA2 | P00918 | 3/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | FYN | P06241 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4073351 | 0.82 | ACE (0.65) | FOLH1MMEACECPA1ACE2 | |
| SCHEMBL2545591 | 0.82 | ACE (0.65) | FOLH1MMEACECPA1ACE2 | |
| SCHEMBL31287928 | 0.82 | ACE (0.65) | FOLH1MMEACECPA1ACE2 | |
| SCHEMBL2493049 | 0.82 | ACE (0.65) | FOLH1MMEACECPA1ACE2 | |
| Water SCHEMBL20495306 | 0.81 | ACE (0.64) | FOLH1MMEACECPA1ACE2 | |
| Water SCHEMBL20489335 | 0.81 | ACE (0.64) | FOLH1MMEACECPA1ACE2 | |
| Water SCHEMBL29167818 | 0.81 | ACE (0.64) | FOLH1MMEACECPA1ACE2 | |
| Water SCHEMBL20489337 | 0.81 | ACE (0.64) | FOLH1MMEACECPA1ACE2 | |
| Water SCHEMBL29167817 | 0.81 | ACE (0.64) | FOLH1MMEACECPA1ACE2 | |
| Water SCHEMBL29167821 | 0.81 | ACE (0.64) | FOLH1MMEACECPA1ACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3145944-B1 | MACROCYCLIC BROAD SPECTRUM ANTIBIOTICS | RQX PHARMACEUTICALS INC (US) | 2021-05-05 | — | — | EP | disclosed |