Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 13/20 | 0.60 |
| ▸ | FGFR4 | P22455 | 14/20 | 0.51 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.51 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CSF1R | P07333 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15412800 | 0.87 | FGFR1 (0.78) | FGFR1FGFR4FGFR2FGFR3CYP1A2 | |
| SCHEMBL15434027 | 0.83 | FGFR1 (0.54) | FGFR1FGFR4FGFR2FGFR3CYP1A2 | |
| SCHEMBL15413005 | 0.80 | FGFR1 (0.52) | FGFR1FGFR4FGFR2FGFR3CYP1A2 | |
| SCHEMBL16941551 | 0.79 | FGFR1 (0.78) | FGFR1FGFR4FGFR2FGFR3CYP1A2 | |
| SCHEMBL23314941 | 0.79 | FGFR1 (0.77) | FGFR1FGFR4FGFR2FGFR3CYP1A2 | |
| SCHEMBL20705982 | 0.78 | FGFR1 (0.49) | FGFR1FGFR4FGFR2FGFR3CYP1A2 | |
| SCHEMBL15854314 | 0.76 | FGFR1 (0.52) | FGFR1FGFR4FGFR2FGFR3CYP1A2 | |
| SCHEMBL19508321 | 0.76 | FGFR1 (0.64) | FGFR1FGFR4FGFR2FGFR3CYP1A2 | |
| SCHEMBL19508048 | 0.76 | FGFR1 (0.63) | FGFR1FGFR4FGFR2FGFR3CYP1A2 | |
| SCHEMBL15413160 | 0.75 | FGFR1 (1.00) | FGFR1FGFR4FGFR2FGFR3CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2872491-B1 | INHIBITORS OF THE FIBROBLAST GROWTH FACTOR RECEPTOR | BLUEPRINT MEDICINES CORP (US) | 2021-05-05 | — | — | EP | disclosed |