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SCHEMBL23314947

SCHEMBL23314947

C=CC(=C)Nc1ccccc1Nc1cc2nc(NC(=O)NC(C)(C)C)c(-c3cc(OC)cc(OC)c3)cc2cn1

nearest known ligand 0.88

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ FGFR4 P22455 12/20 0.88
▸ FGFR1 P11362 18/20 0.69
▸ SRC P12931 1/20 0.67
▸ KDR P35968 15/20 0.63
▸ FGFR2 P21802 10/20 0.61
▸ FGFR3 P22607 10/20 0.61
▸ FLT1 P17948 9/20 0.61
▸ FLT4 P35916 9/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15434030 0.94 FGFR4 (1.00) FGFR4FGFR1SRCKDRFGFR2
SCHEMBL14040752 0.81 FGFR1 (1.00) FGFR4FGFR1SRCKDRFGFR2
SCHEMBL16367921 0.79 FGFR4 (0.75) FGFR4FGFR1SRCKDRFGFR2
SCHEMBL16868903 0.72 FGFR1 (1.00) FGFR4FGFR1SRCKDRFGFR2
SCHEMBL26928578 0.70 FGFR1 (1.00) FGFR4FGFR1KDRFGFR2FGFR3
SCHEMBL30737915 0.70 FGFR1 (1.00) FGFR4FGFR1KDRFGFR2FGFR3
SCHEMBL15433994 0.69 FGFR4 (1.00) FGFR4FGFR1SRCFGFR2FGFR3
SCHEMBL1248489 0.69 FGFR1 (1.00) FGFR4FGFR1SRCKDRFGFR2
SCHEMBL29366761 0.69 FGFR1 (1.00) FGFR4FGFR1SRCKDRFGFR2
SCHEMBL18612797 0.68 FGFR4 (0.62) FGFR4FGFR1KDRFGFR2FGFR3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2872491-B1 INHIBITORS OF THE FIBROBLAST GROWTH FACTOR RECEPTOR BLUEPRINT MEDICINES CORP (US) 2021-05-05 — — EP disclosed
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