Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 16/20 | 0.80 |
| ▸ | FGFR1 | P11362 | 11/20 | 0.80 |
| ▸ | FGFR2 | P21802 | 4/20 | 0.79 |
| ▸ | FGFR3 | P22607 | 4/20 | 0.79 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.79 |
| ▸ | CSF1R | P07333 | 1/20 | 0.79 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.79 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.79 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.79 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.79 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15433992 | 0.89 | FGFR4 (1.00) | FGFR4FGFR1FGFR2FGFR3CYP1A2 | |
| SCHEMBL15412407 | 0.88 | FGFR4 (1.00) | FGFR4FGFR1FGFR2FGFR3CYP1A2 | |
| SCHEMBL15413472 | 0.82 | FGFR4 (0.70) | FGFR4FGFR1FGFR2FGFR3CYP1A2 | |
| SCHEMBL15434025 | 0.82 | FGFR4 (1.00) | FGFR4FGFR1FGFR2FGFR3CYP1A2 | |
| SCHEMBL15412858 | 0.81 | FGFR1 (1.00) | FGFR4FGFR1FGFR2FGFR3CYP1A2 | |
| SCHEMBL15434006 | 0.81 | FGFR4 (1.00) | FGFR4FGFR1FGFR2FGFR3CYP1A2 | |
| SCHEMBL15413317 | 0.80 | FGFR4 (0.73) | FGFR4FGFR1FGFR2FGFR3CYP1A2 | |
| SCHEMBL15433996 | 0.79 | FGFR4 (1.00) | FGFR4FGFR1FGFR2FGFR3CYP1A2 | |
| SCHEMBL15433997 | 0.79 | FGFR4 (1.00) | FGFR4FGFR1FGFR2FGFR3CYP1A2 | |
| SCHEMBL15434022 | 0.79 | FGFR4 (1.00) | FGFR4FGFR1FGFR2FGFR3CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2872491-B1 | INHIBITORS OF THE FIBROBLAST GROWTH FACTOR RECEPTOR | BLUEPRINT MEDICINES CORP (US) | 2021-05-05 | — | — | EP | disclosed |