⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3179245 | 0.90 | — | — | |
| SCHEMBL415867 | 0.88 | — | — | |
| SCHEMBL971638 | 0.79 | — | — | |
| SCHEMBL22779 | 0.79 | — | — | |
| SCHEMBL70430 | 0.73 | — | — | |
| SCHEMBL8528851 | 0.65 | — | — | |
| SCHEMBL4083 | 0.63 | — | — | |
| Hydrochloric Acid SCHEMBL3262873 | 0.59 | — | — | |
| Tetrahydrofuran SCHEMBL5616324 | 0.57 | — | — | |
| Tetrahydrofuran SCHEMBL6298732 | 0.55 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 607 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023144053-A1 | HETEROCYCLIC DERIVATIVES | MERCK PATENT GMBH (DE) | 2023-08-03 | — | — | WO | claimed |
| US-20220062258-A1 | Heterocyclic derivatives | MERCK PATENT GMBH (DE) | 2022-03-03 | — | — | US | claimed |
| CN-108699053-B | 4-hydroxy-2-phenyl-1, 3-thiazol-5-yl methanone derivatives as TRPM8 antagonists | 东佩制药股份公司 | 2022-01-14 | — | — | CN | claimed |
| EP-3394053-B1 | (4-HYDROXY-2-PHENYL-1,3-THIAZOL-5-YL) METHANONE DERIVATIVES AS TRPM8 ANTAGONISTS | DOMPE FARM SPA (IT) | 2019-08-21 | — | — | EP | claimed |
| US-10246448-B2 | 4-hydroxy-2-phenyl-1,3-thiazol-5-yl methanone derivatives as TRPM8 antagonists | DOMPÉ FARMACEUTICI S.P.A. (IT) | 2019-04-02 | — | — | US | claimed |
| US-20180319785-A1 | 4-HYDROXY-2-PHENYL-1,3-THIAZOL-5-YL METHANONE DERIVATIVES AS TRPM8 ANTAGONISTS | DOMPÉ FARMACEUTICI S.P.A. (IT) | 2018-11-08 | — | — | US | claimed |
| EP-3286346-A1 | METHODS FOR SELECTIVE LEACHING AND EXTRACTION OF PRECIOUS METALS IN ORGANIC SOLVENTS | University of Saskatchewan (CA) | 2018-02-28 | — | — | EP | claimed |
| EP-3184524-A1 | 4-HYDROXY-2-PHENYL-1,3-THIAZOL-5-YL METHANONE DERIVATIVES AS TRPM8 ANTAGONISTS | Dompé farmaceutici S.p.A. (IT) | 2017-06-28 | — | — | EP | claimed |
| US-9630934-B2 | Fumarate compounds, pharmaceutical compositions thereof, and methods of use | Nguyen, Mark Quang (US) | 2017-04-25 | — | — | US | claimed |
| US-20160297770-A1 | FUMARATE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USE | NGUYEN MARK QUANG (US) | 2016-10-13 | — | — | US | claimed |
| WO-2012048775-A1 | PYRROLIDINONES AS METAP2 INHIBITORS | MERCK PATENT GMBH (DE) | 2012-04-19 | — | — | WO | claimed |
| WO-2012041435-A1 | PHENYLQUINAZOLINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2012-04-05 | — | — | WO | claimed |
| EP-2318363-A1 | HETEROCYCLIC DERIVATIVES AS IAP BINDING COMPOUNDS | Nuevolution A/S (DK) | 2011-05-11 | — | — | EP | claimed |
| WO-2009152824-A1 | HETEROCYCLIC DERIVATIVES AS IAP BINDING COMPOUNDS | NUEVOLUTION A/S (DK) | 2009-12-23 | — | — | WO | claimed |
| EP-0390215-B1 | Quinolone derivatives and salts thereof, preparation process es thereof, and antibacterial agents containing the same | WAKUNAGA SEIYAKU KK (JP) | 1995-06-07 | — | — | EP | claimed |
| US-5153203-A | QUINOLONE DERIVATIVES AND SALTS THEREOF, PREPARATION PROCESSES THEREOF, AND ANTIBACTERIAL AGENTS CONTAINING THE SAME | WAKUNAGA SEIYAKU KABUSHIKI KAISHA (JP) | 1992-10-06 | — | — | US | claimed |
| EP-0390215-A2 | Quinolone derivatives and salts thereof, preparation process es thereof, and antibacterial agents containing the same | WAKUNAGA SEIYAKU KABUSHIKI KAISHA (JP) | 1990-10-03 | — | — | EP | claimed |
| US-4576749-A | 3-Acylamino-1-carboxymethylaminocarbonyl-2-azetidinones | E. R. SQUIBB & SONS, INC. (US) | 1986-03-18 | — | — | US | claimed |
| EP-0138407-A1 | Azetidinones | E.R. Squibb & Sons, Inc. (US) | 1985-04-24 | — | — | EP | claimed |
| US-3997528-A | BACTERICIDES | SHIONOGI & CO., LTD. (JA) | 1976-12-14 | — | — | US | claimed |