Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.51 |
| ▸ | HRH4 | Q9H3N8 | 7/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13453646 | 0.83 | HRH4 (0.37) | HRH3HRH4SIGMAR1ALDH1A1SLC6A2 | |
| SCHEMBL23838502 | 0.82 | HRH4 (0.44) | HRH3HRH4SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL13453642 | 0.81 | SMPD1 (0.41) | HRH3HRH4 | |
| SCHEMBL12300921 | 0.80 | HRH4 (0.45) | HRH3HRH4DRD2DRD4DRD3 | |
| SCHEMBL12247046 | 0.79 | HRH4 (0.43) | HRH3HRH4DRD2DRD4DRD3 | |
| SCHEMBL18377710 | 0.79 | HRH3 (0.55) | HRH3HRH4SIGMAR1ALDH1A1DRD2 | |
| SCHEMBL25715688 | 0.78 | SMPD1 (0.42) | HRH3HRH4 | |
| SCHEMBL13242529 | 0.78 | FLT3 (0.46) | HRH3HRH4IRAK4SIGMAR1ALDH1A1 | |
| SCHEMBL13469513 | 0.77 | DPP4 (0.36) | HRH3HRH4SIGMAR1SLC6A2SLC6A4 | |
| SCHEMBL19705750 | 0.77 | HRH4 (0.37) | HRH3HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230145782-A1 | p53 MODULATORS AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2023-05-11 | — | — | US | disclosed |
| WO-2021087096-A1 | P53 MODULATORS AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2021-05-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230145782-A1 | p53 MODULATORS AND USES THEREOF | TP53, TP53BP1, MDM2 | HRH3 4688/4885HRH4 4543/4885MEN1 3588/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.