Sugi Predict

Sugi Predict / Compounds / SCHEMBL23323567

SCHEMBL23323567

SCHEMBL23323567

CC(C)N1CCC2(CCN(C(=O)N(C)C(C)C)CC2)CC1

nearest known ligand 0.39

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
▸ CYP2D6 P10635 6/20 0.39
▸ CYP2C19 P33261 1/20 0.39
▸ CYP2C9 P11712 3/20 0.38
▸ CYP3A4 P08684 3/20 0.38
▸ ALDH1A1 P00352 2/20 0.38
▸ HRH3 Q9Y5N1 9/20 0.37
▸ CYP1A2 P05177 2/20 0.37
▸ USP2 O75604 1/20 0.33
▸ MAPK1 P28482 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23323568 0.90 HRH3 (0.39) CYP2D6CYP2C19CYP2C9CYP3A4ALDH1A1
SCHEMBL23324887 0.88 HRH3 (0.43) CYP2D6CYP2C19CYP2C9CYP3A4ALDH1A1
SCHEMBL23323478 0.88 CYP3A4 (0.39) CYP2D6CYP2C19CYP2C9CYP3A4ALDH1A1
SCHEMBL23325421 0.85 HRH3 (0.39) CYP2D6CYP2C19CYP2C9CYP3A4ALDH1A1
SCHEMBL20346243 0.83 HRH3 (0.44) CYP2D6HRH3
SCHEMBL25884737 0.83 HRH3 (0.36) CYP2D6CYP2C19CYP2C9CYP3A4ALDH1A1
SCHEMBL23323569 0.83 CYP3A4 (0.44) CYP2D6CYP2C19CYP2C9CYP3A4ALDH1A1
SCHEMBL23323571 0.83 HRH3 (0.42) CYP2D6CYP2C19CYP2C9CYP3A4ALDH1A1
SCHEMBL23325022 0.79 CYP2D6 (0.36) CYP2D6CYP2C19CYP2C9CYP3A4ALDH1A1
SCHEMBL24918193 0.78 CYP2C9 (0.57) CYP2D6CYP2C19CYP2C9CYP3A4ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230234929-A1 RAS INHIBITORS WILMINGTON TRUST, NATIONAL ASSOCIATION, AS AGENT 2023-07-27 — — US disclosed
US-20230233569-A1 METHODS FOR DELAYING, PREVENTING, AND TREATING ACQUIRED RESISTANCE TO RAS INHIBITORS WILMINGTON TRUST, NATIONAL ASSOCIATION, AS AGENT 2023-07-27 — — US disclosed
US-20230234929-A1 RAS INHIBITORS WILMINGTON TRUST, NATIONAL ASSOCIATION, AS AGENT 2023-07-27 — — US disclosed
US-20230233569-A1 METHODS FOR DELAYING, PREVENTING, AND TREATING ACQUIRED RESISTANCE TO RAS INHIBITORS WILMINGTON TRUST, NATIONAL ASSOCIATION, AS AGENT 2023-07-27 — — US disclosed
US-11566007-B2 Ras inhibitors Revolution Medicines, Inc. (US) 2023-01-31 — — US disclosed
US-20210130303-A1 RAS INHIBITORS WILMINGTON TRUST, NATIONAL ASSOCIATION, AS AGENT 2021-05-06 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11566007-B2 Ras inhibitors KRAS, NRAS, HRAS CYP2D6 3178/4885CYP2C19 3930/4885CYP2C9 3961/4885
US-20230234929-A1 RAS INHIBITORS KRAS, NRAS, HRAS CYP2D6 3178/4885CYP2C19 3930/4885CYP2C9 3961/4885
US-20230233569-A1 METHODS FOR DELAYING, PREVENTING, AND TREATING ACQUIRED RESISTANCE TO RAS INHIBITORS KRAS, HRAS, MTOR CYP2D6 4714/4885CYP2C19 4869/4885CYP2C9 4876/4885
US-20210130303-A1 RAS INHIBITORS KRAS, NRAS, HRAS CYP2D6 3178/4885CYP2C19 3930/4885CYP2C9 3961/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.