Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23685382 | 0.99 | KRAS (0.75) | KRASSOS1 | |
| SCHEMBL24660321 | 0.92 | KRAS (0.67) | KRASSOS1 | |
| SCHEMBL23308440 | 0.92 | KRAS (0.65) | KRASSOS1 | |
| SCHEMBL25887398 | 0.89 | KRAS (0.79) | KRASSOS1 | |
| SCHEMBL22848335 | 0.88 | KRAS (0.60) | KRASSOS1 | |
| SCHEMBL23308441 | 0.88 | KRAS (0.60) | KRASSOS1 | |
| SCHEMBL23308453 | 0.88 | KRAS (0.60) | KRASSOS1 | |
| SCHEMBL24660281 | 0.87 | KRAS (0.59) | KRASSOS1 | |
| SCHEMBL24574302 | 0.87 | KRAS (0.60) | KRASSOS1 | |
| SCHEMBL23308452 | 0.87 | KRAS (0.57) | KRASSOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11697657-B2 | Small molecule inhibitors of KRAS G12C mutant | MERCK SHARP & DOHME LLC (US) | 2023-07-11 | — | — | US | disclosed |
| WO-2021086833-A1 | SMALL MOLECULE INHIBITORS OF KRAS G12C MUTANT | MERCK SHARP & DOHME CORP. (US) | 2021-05-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11697657-B2 | Small molecule inhibitors of KRAS G12C mutant | KRAS, NRAS, HRAS | KRAS 1/4885SOS1 320/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.