Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR3 | P22607 | 2/20 | 0.68 |
| ▸ | FGFR1 | P11362 | 18/20 | 0.64 |
| ▸ | PDGFRB | P09619 | 16/20 | 0.64 |
| ▸ | KDR | P35968 | 16/20 | 0.64 |
| ▸ | FLT1 | P17948 | 5/20 | 0.64 |
| ▸ | LCK | P06239 | 2/20 | 0.52 |
| ▸ | FLT3 | P36888 | 2/20 | 0.52 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.52 |
| ▸ | PLK4 | O00444 | 1/20 | 0.52 |
| ▸ | STK25 | O00506 | 1/20 | 0.52 |
| ▸ | CIT | O14578 | 1/20 | 0.52 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.52 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.52 |
| ▸ | GAK | O14976 | 1/20 | 0.52 |
| ▸ | CHUK | O15111 | 1/20 | 0.52 |
| ▸ | MUSK | O15146 | 1/20 | 0.52 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.52 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.52 |
| ▸ | MAP3K13 | O43283 | 1/20 | 0.52 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20625528 | 1.00 | FGFR3 (0.68) | FGFR3FGFR1PDGFRBKDRFLT1 | |
| SCHEMBL20625529 | 1.00 | FGFR3 (0.68) | FGFR3FGFR1PDGFRBKDRFLT1 | |
| SCHEMBL20625447 | 0.94 | FGFR3 (0.60) | FGFR3FGFR1PDGFRBKDRFLT1 | |
| SCHEMBL23326253 | 0.94 | FGFR3 (0.60) | FGFR3FGFR1PDGFRBKDRFLT1 | |
| SCHEMBL20625616 | 0.92 | FGFR1 (0.62) | FGFR3FGFR1PDGFRBKDRFLT1 | |
| SCHEMBL23326078 | 0.92 | FGFR1 (0.62) | FGFR3FGFR1PDGFRBKDRFLT1 | |
| SCHEMBL23326198 | 0.92 | FGFR3 (0.64) | FGFR3FGFR1PDGFRBKDRFLT1 | |
| SCHEMBL20624951 | 0.92 | FGFR3 (0.64) | FGFR3FGFR1PDGFRBKDRFLT1 | |
| SCHEMBL20625272 | 0.92 | FGFR3 (0.58) | FGFR3FGFR1PDGFRBKDRFLT1 | |
| SCHEMBL20625271 | 0.92 | FGFR3 (0.58) | FGFR3FGFR1PDGFRBKDRFLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111032643-B | Quinolinone compounds | 詹森药业有限公司 | 2023-05-30 | — | — | CN | disclosed |
| US-11384075-B2 | Quinolinone compounds | JANSSEN PHARMACEUTICA NV (BE) | 2022-07-12 | — | — | US | disclosed |
| US-11384075-B2 | Quinolinone compounds | JANSSEN PHARMACEUTICA NV (BE) | 2022-07-12 | — | — | US | disclosed |
| US-20210139470-A1 | New Quinolinone Compounds | JOHNSON & JOHNSON (CHINA) INVESTMENT LTD. (CN) | 2021-05-13 | — | — | US | disclosed |
| US-20210139470-A1 | New Quinolinone Compounds | JOHNSON & JOHNSON (CHINA) INVESTMENT LTD. (CN) | 2021-05-13 | — | — | US | disclosed |
| CN-111032643-A | Quinolinone compounds | 詹森药业有限公司 | 2020-04-17 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210139470-A1 | New Quinolinone Compounds | FGFR1, FGFR2, FGFR3 | FGFR3 3/4885FGFR1 1/4885PDGFRB 31/4885 |
| US-11384075-B2 | Quinolinone compounds | FGFR1, FGFR2, FGFR3 | FGFR3 3/4885FGFR1 1/4885PDGFRB 23/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.