SCHEMBL2332844

SCHEMBL2332844

COc1ccc(CN([C@H]2CCN(Cc3cccc(C#N)c3)C2=O)S(=O)(=O)c2ccc3ccc(OC)cc3c2)cc1

nearest known ligand 0.69

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
F10 P00742 16/20 0.69
F2 P00734 12/20 0.69
KLK6 Q92876 3/20 0.61
PLG P00747 2/20 0.52
PROC P04070 2/20 0.52
PLAT P00750 1/20 0.52
PRSS1 P07477 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2332734 0.96 F10 (0.67) F10F2KLK6PLGPROC
SCHEMBL2329857 0.95 F10 (0.68) F10F2KLK6PLGPROC
SCHEMBL2328762 0.95 F10 (0.67) F10F2KLK6PLGPROC
SCHEMBL2329198 0.94 F10 (0.66) F10F2KLK6PLGPROC
SCHEMBL2329161 0.94 F10 (0.65) F10F2KLK6PLGPROC
SCHEMBL2328754 0.94 F10 (0.64) F10F2KLK6PLGPROC
SCHEMBL2329476 0.93 F10 (0.66) F10F2KLK6PLGPROC
SCHEMBL2328320 0.93 F10 (0.64) F10F2KLK6PLGPROC
SCHEMBL2328912 0.92 F10 (0.73) F10F2KLK6PLGPROC
SCHEMBL2331021 0.91 F10 (0.62) F10F2KLK6PLGPROC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0853618-B1 SUBSTITUTED (SULFINIC ACID, SULFONIC ACID, SULFONYLAMINO OR SULFINYLAMINO) N- (AMINOIMINOMETHYL)PHENYLALKYL -AZAHETEROCYCLYLAMIDE COMPOUNDS AVENTIS PHARMA INC (US) 2011-08-17 EP disclosed
US-5958918-A Substituted (sulfinic acid, sulfonic acid, sulfonylamino or sulfinylamino) N- (aminominomethyl)phenylalkyl!-azaheterocyclylamide compounds RHONE-POULENC RORER PHARMACEUTICALS INC. 1999-09-28 US disclosed