Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD38 | P28907 | 11/20 | 0.60 |
| ▸ | CNR2 | P34972 | 7/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | GHSR | Q92847 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23304853 | 0.94 | CD38 (0.64) | CD38CNR2GSK3BDYRK1A | |
| SCHEMBL24962684 | 0.88 | CD38 (0.59) | CD38GSK3BDYRK1AGHSR | |
| SCHEMBL24962697 | 0.85 | CD38 (0.59) | CD38CNR2 | |
| SCHEMBL23329085 | 0.85 | CD38 (0.59) | CD38CNR2 | |
| SCHEMBL24963464 | 0.81 | CD38 (0.60) | CD38GHSR | |
| SCHEMBL23329432 | 0.79 | CD38 (0.62) | CD38GHSR | |
| SCHEMBL23329856 | 0.79 | CD38 (0.79) | CD38 | |
| SCHEMBL23304684 | 0.78 | CD38 (0.74) | CD38 | |
| SCHEMBL23329203 | 0.76 | CD38 (0.85) | CD38 | |
| SCHEMBL23329147 | 0.76 | CD38 (0.85) | CD38 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021087087-A1 | N-CYCLOHEXYL-5-(THIAZOL-5-YL)-1H-INDOLE-7-CARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS CD38 INHIBITORS FOR INCREASING NAD+ AND FOR THE TREATMENT OF E.G. MUSCULAR DISORDERS | MITOBRIDGE INC. (US) | 2021-05-06 | — | — | WO | disclosed |