Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR3 | P22607 | 5/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | EGFR | P00533 | 8/20 | 0.46 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.46 |
| ▸ | JAK3 | P52333 | 3/20 | 0.46 |
| ▸ | JAK2 | O60674 | 2/20 | 0.46 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.46 |
| ▸ | SIK1 | P57059 | 1/20 | 0.46 |
| ▸ | MELK | Q14680 | 1/20 | 0.46 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.46 |
| ▸ | SIK3 | Q9Y2K2 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 3/20 | 0.42 |
| ▸ | LCK | P06239 | 2/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2330369 | 0.90 | FGFR3 (0.61) | FGFR3CYP3A4CYP2C9CYP2C19EGFR | |
| SCHEMBL374407 | 0.83 | FGFR3 (0.63) | FGFR3CYP3A4CYP2C9CYP2C19EGFR | |
| SCHEMBL374803 | 0.82 | FGFR3 (0.69) | FGFR3CYP3A4CYP2C9CYP2C19EGFR | |
| SCHEMBL374239 | 0.82 | FGFR3 (0.69) | FGFR3CYP3A4CYP2C9CYP2C19EGFR | |
| SCHEMBL374712 | 0.82 | FGFR3 (0.67) | FGFR3CYP3A4CYP2C9CYP2C19EGFR | |
| SCHEMBL374019 | 0.81 | FGFR3 (0.59) | FGFR3CYP3A4CYP2C9CYP2C19EGFR | |
| SCHEMBL374466 | 0.81 | FGFR3 (0.72) | FGFR3EGFRERBB3JAK3SIK1 | |
| SCHEMBL13855363 | 0.80 | FGFR3 (0.84) | FGFR3CYP3A4CYP2C9CYP2C19EGFR | |
| SCHEMBL374665 | 0.79 | FGFR3 (0.64) | FGFR3CYP3A4CYP2C9CYP2C19EGFR | |
| SCHEMBL378825 | 0.79 | FGFR3 (0.64) | FGFR3CYP3A4CYP2C9CYP2C19EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761505-B1 | PYRIMIDINE UREA DERIVATIVES AS KINASE INHIBITORS | NOVARTIS AG (CH) | 2011-08-17 | — | — | EP | disclosed |