⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13638931 | 0.86 | — | — | |
| SCHEMBL23335058 | 0.79 | — | — | |
| SCHEMBL21377179 | 0.79 | — | — | |
| SCHEMBL23713803 | 0.79 | — | — | |
| SCHEMBL18530997 | 0.78 | — | — | |
| SCHEMBL25156605 | 0.77 | — | — | |
| SCHEMBL21925387 | 0.76 | TSHR (0.32) | — | |
| SCHEMBL19737665 | 0.76 | — | — | |
| SCHEMBL24299827 | 0.71 | — | — | |
| SCHEMBL21377183 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11702402-B2 | Small molecules that block proteasome-associated ubiquitin receptor RPN13 function and uses thereof | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2023-07-18 | — | — | US | disclosed |
| US-20210130324-A1 | SMALL MOLECULES THAT BLOCK PROTEASOME-ASSOCIATED UBIQUITIN RECEPTOR RPN13 FUNCTION AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2021-05-06 | — | — | US | disclosed |