Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | BPTF | Q12830 | 3/20 | 0.36 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | MELK | Q14680 | 1/20 | 0.34 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.34 |
| ▸ | CCNK | O75909 | 1/20 | 0.34 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | CDK9 | P50750 | 1/20 | 0.34 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.34 |
| ▸ | KMT5B | Q4FZB7 | 2/20 | 0.33 |
| ▸ | KMT5C | Q86Y97 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.33 |
| ▸ | IKBKB | O14920 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24950011 | 1.00 | MEN1 (0.37) | MEN1KMT2ABPTFCSNK2BPIM1 | |
| SCHEMBL23335274 | 0.95 | BPTF (0.38) | MEN1KMT2ABPTFMELKCCNT1 | |
| SCHEMBL17119701 | 0.89 | KMT2A (0.44) | MEN1KMT2ABPTFCSNK2BKMT5B | |
| SCHEMBL17119633 | 0.88 | KMT2A (0.46) | MEN1KMT2ACSNK2BKMT5BKMT5C | |
| SCHEMBL24950187 | 0.87 | BPTF (0.47) | BPTFPIK3CA | |
| SCHEMBL24949759 | 0.87 | BPTF (0.47) | BPTFPIK3CA | |
| SCHEMBL23335575 | 0.86 | KMT2A (0.49) | MEN1KMT2ACSNK2BKMT5BKMT5C | |
| SCHEMBL24950104 | 0.86 | BPTF (0.50) | BPTFCCNT1CCNKCCNE1CDK2 | |
| SCHEMBL23335316 | 0.86 | BPTF (0.50) | BPTFCCNT1CCNKCCNE1CDK2 | |
| SCHEMBL23884983 | 0.85 | MEN1 (0.38) | MEN1KMT2ACSNK2BPIM1KMT5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230014742-A1 | BICYCLIC NITROGEN CONTAINING HETEROCYCLES AS INHIBITORS OF SALT-INDUCED KINASE SIK2 | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2023-01-19 | — | — | US | disclosed |
| WO-2021084266-A1 | BICYCLIC NITROGEN CONTAINING HETEROCYCLES AS INHIBITORS OF SALT-INUCED KINASE SIK2 | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2021-05-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230014742-A1 | BICYCLIC NITROGEN CONTAINING HETEROCYCLES AS INHIBITORS OF SALT-INDUCED KINASE SIK2 | SIK2, SIK1, SIK3 | MEN1 1476/4885KMT2A 1107/4885BPTF 1318/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.