Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK7 | P50613 | 15/20 | 0.66 |
| ▸ | CCNK | O75909 | 11/20 | 0.66 |
| ▸ | CDK12 | Q9NYV4 | 11/20 | 0.66 |
| ▸ | CDK9 | P50750 | 10/20 | 0.66 |
| ▸ | CDK2 | P24941 | 10/20 | 0.66 |
| ▸ | CCNH | P51946 | 9/20 | 0.66 |
| ▸ | CCNT1 | O60563 | 9/20 | 0.66 |
| ▸ | MNAT1 | P51948 | 7/20 | 0.66 |
| ▸ | JUN | P05412 | 4/20 | 0.55 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.55 |
| ▸ | MAPK9 | P45984 | 4/20 | 0.55 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.52 |
| ▸ | CDK13 | Q14004 | 4/20 | 0.51 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.51 |
| ▸ | CDK3 | Q00526 | 1/20 | 0.51 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.50 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16654935 | 0.89 | CDK7 (0.67) | CDK7CCNKCDK12CDK9CDK2 | |
| SCHEMBL23040295 | 0.89 | CDK7 (0.67) | CDK7CCNKCDK12CDK9CDK2 | |
| SCHEMBL17688421 | 0.88 | CDK7 (0.71) | CDK7CCNKCDK12CDK9CDK2 | |
| SCHEMBL16654788 | 0.88 | CDK7 (0.71) | CDK7CCNKCDK12CDK9CDK2 | |
| SCHEMBL16654786 | 0.85 | CDK7 (0.74) | CDK7CCNKCDK12CDK9CDK2 | |
| SCHEMBL16665154 | 0.85 | CDK7 (0.67) | CDK7CCNKCDK12CDK9CDK2 | |
| SCHEMBL17696320 | 0.85 | CDK7 (0.67) | CDK7CCNKCDK12CDK9CDK2 | |
| SCHEMBL16665178 | 0.85 | CDK7 (0.88) | CDK7CCNKCDK12CDK9CDK2 | |
| SCHEMBL18072745 | 0.85 | CDK7 (0.88) | CDK7CCNKCDK12CDK9CDK2 | |
| SCHEMBL16665179 | 0.85 | CDK7 (0.88) | CDK7CCNKCDK12CDK9CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3057956-B1 | POLYCYCLIC INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) | DANA FARBER CANCER INST INC (US) | 2021-05-05 | — | — | EP | disclosed |