Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.60 |
| ▸ | PPARG | P37231 | 1/20 | 0.60 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.60 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 6/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | CCNC | P24863 | 1/20 | 0.58 |
| ▸ | CDK8 | P49336 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | STAT1 | P42224 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31089964 | 0.91 | SMN1; SMN2 (0.58) | RXFP1PPARGNR2E3NCOR2HTT | |
| SCHEMBL11846406 | 0.91 | KDM4E (0.63) | RXFP1PPARGNR2E3NCOR2HTT | |
| SCHEMBL15923148 | 0.89 | SMN1; SMN2 (0.67) | RXFP1PPARGNR2E3NCOR2HTT | |
| SCHEMBL31197395 | 0.89 | SMN1; SMN2 (0.67) | RXFP1PPARGNR2E3NCOR2HTT | |
| SCHEMBL15924449 | 0.89 | SMN1; SMN2 (0.67) | RXFP1PPARGNR2E3NCOR2HTT | |
| SCHEMBL11855329 | 0.86 | HDAC1 (0.60) | RXFP1PPARGNR2E3NCOR2HTT | |
| SCHEMBL11857739 | 0.86 | HDAC1 (0.60) | RXFP1PPARGNR2E3NCOR2HTT | |
| SCHEMBL11849897 | 0.86 | HDAC1 (0.60) | RXFP1PPARGNR2E3NCOR2HTT | |
| SCHEMBL18290260 | 0.84 | RXFP1 (0.56) | RXFP1PPARGNR2E3NCOR2HTT | |
| SCHEMBL24652841 | 0.84 | RXFP1 (0.56) | RXFP1PPARGNR2E3NCOR2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022250971-A1 | SMALL MOLECULE INHIBITORS OF AUTOPHAGY AND HISTONE DEACTYLASES AND USES THEREOF | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2022-12-01 | — | — | WO | disclosed |
| WO-2021087077-A1 | SMALL MOLECULE INHIBITORS OF AUTOPHAGY AND HISTONE DEACTYLASES AND USES THEREOF | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2021-05-06 | — | — | WO | disclosed |