Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 6/20 | 0.40 |
| ▸ | ATAD2 | Q6PL18 | 6/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 13/20 | 0.38 |
| ▸ | CDK2 | P24941 | 13/20 | 0.38 |
| ▸ | CCND1 | P24385 | 9/20 | 0.38 |
| ▸ | CDK6 | Q00534 | 9/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.38 |
| ▸ | CDK4 | P11802 | 1/20 | 0.38 |
| ▸ | CDK9 | P50750 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | TAF1 | P21675 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23340894 | 0.90 | BRD4 (0.45) | BRD4ATAD2CCNE1CDK2CCND1 | |
| SCHEMBL23341176 | 0.83 | BRD4 (0.46) | BRD4ATAD2CCNE1CDK2CCND1 | |
| SCHEMBL23340720 | 0.81 | CCNE1 (0.46) | CCNE1CDK2CCND1CDK6CCNT1 | |
| SCHEMBL23340848 | 0.81 | BRD4 (0.44) | BRD4ATAD2CCNE1CDK2CCND1 | |
| SCHEMBL23340901 | 0.76 | MAPK14 (0.49) | BRD4ATAD2CCNE1CDK2CCND1 | |
| SCHEMBL19868293 | 0.76 | CCNE1 (0.62) | CCNE1CDK2CCND1CDK6CCNT1 | |
| SCHEMBL23341042 | 0.75 | BRD4 (0.45) | BRD4ATAD2CCNE1CDK2CCND1 | |
| SCHEMBL19868152 | 0.75 | CCNE1 (0.56) | CCNE1CDK2CCND1CDK6CCNT1 | |
| SCHEMBL19868283 | 0.75 | CCNE1 (0.55) | CCNE1CDK2CCND1CDK6CCNT1 | |
| SCHEMBL19868140 | 0.74 | CCNE1 (0.62) | CCNE1CDK2CCND1CDK6CCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3497103-B1 | PYRIDOPYRIMDINONE CDK2/4/6 INHIBITORS | PFIZER (US) | 2021-05-05 | — | — | EP | disclosed |