Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 5/20 | 0.49 |
| ▸ | MAPK9 | P45984 | 4/20 | 0.49 |
| ▸ | MAPK10 | P53779 | 4/20 | 0.49 |
| ▸ | CDK2 | P24941 | 13/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.46 |
| ▸ | CDK7 | P50613 | 3/20 | 0.46 |
| ▸ | CCNH | P51946 | 3/20 | 0.46 |
| ▸ | MNAT1 | P51948 | 3/20 | 0.46 |
| ▸ | CCNK | O75909 | 1/20 | 0.41 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.41 |
| ▸ | CCND1 | P24385 | 11/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 10/20 | 0.39 |
| ▸ | CDK6 | Q00534 | 10/20 | 0.39 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.37 |
| ▸ | CDK4 | P11802 | 5/20 | 0.36 |
| ▸ | CCNT1 | O60563 | 4/20 | 0.36 |
| ▸ | CDK9 | P50750 | 4/20 | 0.36 |
| ▸ | CCND2 | P30279 | 1/20 | 0.35 |
| ▸ | CCND3 | P30281 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23340731 | 0.82 | MAPK8 (0.57) | MAPK8MAPK9MAPK10CDK2CCNA2 | |
| SCHEMBL17910154 | 0.81 | MAPK8 (0.60) | MAPK8MAPK9MAPK10CDK2CCNA2 | |
| SCHEMBL23340786 | 0.80 | MAPK8 (0.55) | MAPK8MAPK9MAPK10CDK2CCNA2 | |
| SCHEMBL23340913 | 0.80 | MAPK8 (0.54) | MAPK8MAPK9MAPK10CDK2CCNA2 | |
| SCHEMBL19868166 | 0.80 | CDK2 (0.59) | MAPK8MAPK9MAPK10CDK2CCNA2 | |
| SCHEMBL23341021 | 0.77 | MAPK8 (0.48) | MAPK8MAPK9MAPK10CDK2CCNA2 | |
| SCHEMBL23341018 | 0.76 | MAPK8 (0.51) | MAPK8MAPK9MAPK10CDK2CCNA2 | |
| SCHEMBL19868272 | 0.76 | CDK2 (0.59) | MAPK8MAPK9MAPK10CDK2CCNA2 | |
| SCHEMBL23340842 | 0.75 | MAPK8 (0.50) | MAPK8MAPK9MAPK10CDK2CCNA2 | |
| SCHEMBL19868137 | 0.75 | CCNE1 (0.61) | MAPK8MAPK9MAPK10CDK2CCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3497103-B1 | PYRIDOPYRIMDINONE CDK2/4/6 INHIBITORS | PFIZER (US) | 2021-05-05 | — | — | EP | disclosed |