Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH2 | P48735 | 6/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.45 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | METAP2 | P50579 | 2/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | SLC6A9 | P48067 | 4/20 | 0.42 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
| ▸ | CAMK1D | Q8IU85 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23341085 | 1.00 | IDH2 (0.52) | IDH2LMNACCNE2CCNE1CDK2 | |
| SCHEMBL20180775 | 0.83 | HDAC6 (0.47) | IDH2CCNE2CCNE1CDK2HDAC6 | |
| SCHEMBL19574003 | 0.83 | HDAC6 (0.47) | IDH2CCNE2CCNE1CDK2HDAC6 | |
| SCHEMBL14314163 | 0.82 | TLR7 (0.45) | LMNAKDM4EUSP2ALOX15TSHR | |
| SCHEMBL355858 | 0.81 | LCAT (0.48) | IDH2LMNAMETAP2SLC6A3GABRA1 | |
| SCHEMBL23246818 | 0.80 | HDAC6 (0.50) | IDH2CCNE2CCNE1CDK2HDAC6 | |
| SCHEMBL19145301 | 0.80 | HDAC6 (0.50) | IDH2HDAC6KDM4EHSD17B10AOC3 | |
| SCHEMBL29729367 | 0.79 | EIF2AK4 (0.57) | IDH2LMNAKDM4EUSP2ALOX15 | |
| SCHEMBL29729356 | 0.78 | EIF2AK4 (0.49) | LMNAKDM4EUSP2ALOX15TSHR | |
| SCHEMBL24968333 | 0.78 | OGA (0.46) | IDH2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021087025-A1 | PYRIDAZINONES AS PARP7 INHIBITORS | RIBON THERAPEUTICS, INC. (US) | 2021-05-06 | — | — | WO | disclosed |