Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOX | P28300 | 1/20 | 0.46 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.46 |
| ▸ | KCNB1 | Q14721 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.36 |
| ▸ | AAK1 | Q2M2I8 | 4/20 | 0.35 |
| ▸ | CCR1 | P32246 | 1/20 | 0.35 |
| ▸ | CCR5 | P51681 | 1/20 | 0.35 |
| ▸ | CCR8 | P51685 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | ACVR2A | P27037 | 2/20 | 0.35 |
| ▸ | TGFBR2 | P37173 | 2/20 | 0.35 |
| ▸ | ACACB | O00763 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.33 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL84460 | 0.84 | LOX (0.48) | LOXLOXL2KCNB1ROCK2PFKFB3 | |
| SCHEMBL31421700 | 0.84 | LOX (0.48) | LOXLOXL2KCNB1ROCK2PFKFB3 | |
| SCHEMBL12093566 | 0.82 | LOX (0.47) | LOXLOXL2KCNB1ROCK2PFKFB3 | |
| SCHEMBL19863984 | 0.81 | LOX (0.46) | LOXLOXL2KCNB1ROCK2PFKFB3 | |
| SCHEMBL22369466 | 0.81 | LOX (0.50) | LOXLOXL2KCNB1ROCK2PFKFB3 | |
| SCHEMBL9366832 | 0.81 | LOX (0.46) | LOXLOXL2KCNB1ROCK2PFKFB3 | |
| SCHEMBL17000208 | 0.81 | LOX (0.46) | LOXLOXL2KCNB1ROCK2PFKFB3 | |
| SCHEMBL23232590 | 0.81 | LOX (0.50) | LOXLOXL2KCNB1ROCK2PFKFB3 | |
| SCHEMBL21153171 | 0.81 | LOX (0.46) | LOXLOXL2KCNB1ROCK2PFKFB3 | |
| SCHEMBL23232245 | 0.81 | LOX (0.50) | LOXLOXL2KCNB1ROCK2PFKFB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11001575-B1 | Benzolactam compounds as protein kinase inhibitors | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2021-05-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11001575-B1 | Benzolactam compounds as protein kinase inhibitors | MAPK1, ALK, MAP3K1 | LOX 501/4885LOXL2 1458/4885KCNB1 1135/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.