Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 16/20 | 0.72 |
| ▸ | BRAF | P15056 | 14/20 | 0.72 |
| ▸ | RIPK3 | Q9Y572 | 4/20 | 0.49 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.49 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.49 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.49 |
| ▸ | IKBKB | O14920 | 1/20 | 0.49 |
| ▸ | RAF1 | P04049 | 1/20 | 0.49 |
| ▸ | PDGFA | P04085 | 1/20 | 0.49 |
| ▸ | CDK1 | P06493 | 1/20 | 0.49 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.49 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.49 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.49 |
| ▸ | CDK2 | P24941 | 1/20 | 0.49 |
| ▸ | GSK3B | P49841 | 1/20 | 0.49 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.49 |
| ▸ | TEK | Q02763 | 1/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.49 |
| ▸ | KIT | P10721 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2334728 | 0.92 | KDR (0.61) | KDRBRAFRIPK3PDGFRBRIPK1 | |
| SCHEMBL2332038 | 0.92 | KDR (0.73) | KDRBRAFRIPK3PDGFRBRIPK1 | |
| SCHEMBL2336732 | 0.92 | KDR (0.61) | KDRBRAFRIPK3PDGFRBRIPK1 | |
| SCHEMBL2340231 | 0.91 | KDR (0.72) | KDRBRAFRIPK3PDGFRBRIPK1 | |
| SCHEMBL2340871 | 0.90 | KDR (0.60) | KDRBRAFRIPK3PDGFRBRIPK1 | |
| SCHEMBL2337125 | 0.90 | KDR (0.72) | KDRBRAFRIPK3PDGFRBRIPK1 | |
| SCHEMBL2334383 | 0.86 | KDR (0.62) | KDRBRAFRIPK3PDGFRBRIPK1 | |
| SCHEMBL827315 | 0.84 | BRAF (0.88) | KDRBRAFRIPK3PDGFRBRIPK1 | |
| SCHEMBL823528 | 0.84 | BRAF (0.77) | KDRBRAFRIPK3PDGFRBRIPK1 | |
| SCHEMBL823527 | 0.83 | BRAF (1.00) | KDRBRAFRIPK3PDGFRBRIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2358689-A1 | Benzothiazole derivatives as anticancer agents | Takeda Pharmaceutical Company Limited (JP) | 2011-08-24 | — | — | EP | disclosed |