Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.66 |
| ▸ | MCL1 | Q07820 | 6/20 | 0.66 |
| ▸ | MEN1 | O00255 | 5/20 | 0.66 |
| ▸ | CTDSP1 | Q9GZU7 | 4/20 | 0.66 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.66 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.66 |
| ▸ | APBA1 | Q02410 | 2/20 | 0.66 |
| ▸ | CCR6 | P51684 | 2/20 | 0.66 |
| ▸ | POLB | P06746 | 2/20 | 0.66 |
| ▸ | DUSP3 | P51452 | 2/20 | 0.66 |
| ▸ | USP2 | O75604 | 1/20 | 0.66 |
| ▸ | PKM | P14618 | 1/20 | 0.66 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.65 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.65 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.65 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.63 |
| ▸ | APEX1 | P27695 | 3/20 | 0.55 |
| ▸ | PTGES | O14684 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 6/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2085226 | 1.00 | KMT2A (0.66) | KMT2AMCL1MEN1CTDSP1TDP1 | |
| SCHEMBL12934211 | 0.91 | KMT2A (0.57) | KMT2AMCL1MEN1CTDSP1TDP1 | |
| SCHEMBL14440259 | 0.88 | KMT2A (0.82) | KMT2AMCL1MEN1CTDSP1TDP1 | |
| SCHEMBL2083915 | 0.88 | KMT2A (0.82) | KMT2AMCL1MEN1CTDSP1TDP1 | |
| SCHEMBL5711202 | 0.87 | CACNA1B (0.51) | KMT2AMCL1MEN1CTDSP1TDP1 | |
| SCHEMBL5711204 | 0.87 | CACNA1B (0.51) | KMT2AMCL1MEN1CTDSP1TDP1 | |
| SCHEMBL2085591 | 0.85 | KMT2A (0.70) | KMT2AMCL1MEN1CTDSP1TDP1 | |
| SCHEMBL2085589 | 0.85 | KMT2A (0.70) | KMT2AMCL1MEN1CTDSP1TDP1 | |
| SCHEMBL12445150 | 0.85 | KMT2A (0.70) | KMT2AMCL1MEN1CTDSP1TDP1 | |
| SCHEMBL2084589 | 0.83 | MEN1 (0.64) | KMT2AMCL1MEN1CTDSP1CACNA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1885717-B1 | SHP-2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM AND THEIR USE FOR TREATING PHOSPHATASE-MEDIATED DISEASES | MAX DELBRUECK CENTRUM (DE) | 2011-08-17 | — | — | EP | disclosed |