Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Ceftriaxone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 6/20 | 1.00 |
| ▸ | PGR | P06401 | 3/20 | 1.00 |
| ▸ | PPARG | P37231 | 2/20 | 1.00 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 1.00 |
| ▸ | SLC22A8 | Q8TCC7 | 2/20 | 1.00 |
| ▸ | SLC22A11 | Q9NSA0 | 2/20 | 1.00 |
| ▸ | DAO | P14920 | 1/20 | 1.00 |
| ▸ | SNCA | P37840 | 1/20 | 1.00 |
| ▸ | CYP2J2 | P51589 | 1/20 | 1.00 |
| ▸ | ABCC4 | O15439 | 2/20 | 0.99 |
| ▸ | HTR2C | P28335 | 1/20 | 0.70 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.69 |
| ▸ | MAPT | P10636 | 5/20 | 0.69 |
| ▸ | APEX1 | P27695 | 3/20 | 0.69 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.69 |
| ▸ | POLB | P06746 | 2/20 | 0.69 |
| ▸ | RECQL | P46063 | 2/20 | 0.69 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ceftriaxone SCHEMBL13385441 | 1.00 | NR1I2 (1.00) | NR1I2PGRPPARGSLC22A6SLC22A8 | |
| Ceftriaxone SCHEMBL16072839 | 1.00 | NR1I2 (1.00) | NR1I2PGRPPARGSLC22A6SLC22A8 | |
| Ceftriaxone SCHEMBL23356 | 1.00 | NR1I2 (1.00) | NR1I2PGRPPARGSLC22A6SLC22A8 | |
| Ceftriaxone SCHEMBL5594993 | 1.00 | NR1I2 (1.00) | NR1I2PGRPPARGSLC22A6SLC22A8 | |
| Ceftriaxone SCHEMBL1447498 | 1.00 | NR1I2 (1.00) | NR1I2PGRPPARGSLC22A6SLC22A8 | |
| Ceftriaxone SCHEMBL14896587 | 1.00 | NR1I2 (1.00) | NR1I2PGRPPARGSLC22A6SLC22A8 | |
| Ceftriaxone SCHEMBL18814713 | 1.00 | NR1I2 (1.00) | NR1I2PGRPPARGSLC22A6SLC22A8 | |
| Ceftriaxone SCHEMBL4885124 | 0.99 | NR1I2 (0.99) | NR1I2PGRPPARGSLC22A6SLC22A8 | |
| Ceftriaxone SCHEMBL5846120 | 0.99 | NR1I2 (0.99) | NR1I2PGRPPARGSLC22A6SLC22A8 | |
| Ceftriaxone SCHEMBL28414442 | 0.99 | NR1I2 (0.99) | NR1I2PGRPPARGSLC22A6SLC22A8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 39043 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12636268-B2 | CXCL8 inhibitors for use in the treatment of COVID-19 | DOMPE' FARMACEUTICI SPA (IT) | 2026-05-26 | — | — | US | claimed |
| US-12637481-B2 | Boronic acid derivatives and therapeutic uses thereof | QPEX BIOPHARMA, INC. (US) | 2026-05-26 | — | — | US | claimed |
| WO-2026106551-A1 | ANTIMICROBIAL PEPTIDE NANONETS AND METHODS OF USE THEREOF | NATIONAL UNIVERSITY OF SINGAPORE (SG) | 2026-05-21 | — | — | WO | claimed |
| WO-2026104587-A1 | CYCLIC BORONIC ACID ESTERS USEFUL AS ADJUVANTS IN THE TREATMENT OF BACTERIAL INFECTIONS | ADJUTEC PHARMA AS (NO) | 2026-05-21 | — | — | WO | claimed |
| EP-4743153-A1 | MEDICAL SYSTEMS FOR TREATING CONDITIONS AND DISEASES OF THE PATIENT'S BODY CAVITIES | UTT Urine Topical Treatment Ltd (IL) | 2026-05-20 | — | — | EP | claimed |
| CN-115215923-B | Macrocyclic broad-spectrum antibiotics | 豪夫迈·罗氏有限公司 | 2026-05-19 | — | — | CN | claimed |
| CN-122036889-A | Cyclized antibacterial peptide CycP-1 of targeted multi-drug resistant klebsiella pneumoniae, composition and application thereof | 湖北江夏实验室 | 2026-05-15 | — | — | CN | claimed |
| WO-2026102307-A1 | ACELLULAR BLOOD ALTERNATIVE FOR TRANSFUSION AND ORGAN PERFUSION | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2026-05-15 | — | — | WO | claimed |
| EP-4739326-A2 | PRODUCTION & SECRETION OF AUXIN-LIKE MOLECULES IN BACTERIA | SNIPR Biome ApS (DK) | 2026-05-13 | — | — | EP | claimed |
| US-12622919-B2 | Methods for treating hypervirulent Klebsiella pneumoniae infection | CITY UNIVERSITY OF HONG KONG (CN) | 2026-05-12 | — | — | US | claimed |
| US-4717768-A | Process for separation of syn and anti oxime isomers of cephalosporin-compounds | GLAXO GROUP LIMITED (GB) | 1988-01-05 | — | — | US | claimed |
| EP-0206947-A2 | Pharmaceutical composition containing choline ester salts for enhancing gastrointestinal tract absorption | MERCK & CO. INC. (US) | 1986-12-30 | — | — | EP | claimed |
| EP-0084925-B1 | 6-AMINOALKYLPENICILLANIC ACID 1,1-DIOXIDES AND DERIVATIVES AS BETA-LACTAMASE INHIBITORS | PFIZER INC. (US) | 1986-04-09 | — | — | EP | claimed |
| EP-0148283-A1 | Novel penicillanic acid derivatives | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1985-07-17 | — | — | EP | claimed |
| US-4525339-A | BETA-LACTAM ANTIBIOTIC DISTRIBUTED IN MONO, DI, AND TRI-GLYCERIDES OF FATTY ACIDS | HOFFMANN-LA ROCHE INC. (US) | 1985-06-25 | — | — | US | claimed |
| US-4503040-A | 6-(Aminoacyloxymethyl)penicillanic acid 1,1-dioxides as beta-lactamase inhibitors | PFIZER INC. (US) | 1985-03-05 | — | — | US | claimed |
| US-4452796-A | ANTIBIOTICS | PFIZER INC. (US) | 1984-06-05 | — | — | US | claimed |
| US-4431653-A | ANTIBIOTICS; BACTERICIDES; SSYNERGISTIC WITH AMINO ACID DERIVATIVE | HOFFMANN-LA ROCHE INC. (US) | 1984-02-14 | — | — | US | claimed |
| US-4427678-A | 6-Aminomethylpenicillanic acid 1,1-dioxide derivatives as beta-lactamase inhibitors | PFIZER INC. (US) | 1984-01-24 | — | — | US | claimed |
| EP-0084925-A1 | 6-Aminoalkylpenicillanic acid 1,1-dioxides and derivatives as beta-lactamase inhibitors | PFIZER INC. (US) | 1983-08-03 | — | — | EP | claimed |